中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (8): 674-681. doi: 10.3969/j.issn.1672-6731.2020.08.003

• 专题综述 • 上一篇    下一篇

2 创伤性脑损伤诱发的凝血功能障碍研究进展

徐新, 尚峰, 曲鑫, 王宁   

  1. 100053 北京, 首都医科大学宣武医院神经外科
  • 收稿日期:2020-08-12 出版日期:2020-08-25 发布日期:2020-09-21
  • 通讯作者: 王宁,Email:ningjing_wd@163.com
  • 基金资助:

    首都卫生发展科研专项项目(项目编号:首发2020-2Z-2019)

The research progress of traumatic brain injury-induced coagulopathy

XU Xin, SHANG Feng, QU Xin, WANG Ning   

  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2020-08-12 Online:2020-08-25 Published:2020-09-21
  • Supported by:

    This study was supported by the Capital Health Research and Development of Special (No. 2020-2Z-2019).

摘要:

创伤性脑损伤常诱发凝血功能障碍,表现为导致颅内和全身缺血性损伤的高凝状态,并迅速进展为导致出血性损伤的消耗性低凝状态,二者相互作用,严重影响预后。早期诊断、及时纠正创伤性脑损伤诱发的凝血功能障碍(TBI-IC)业已成为共识,但其发生与发展机制尚未阐明,亦缺乏有效的预防与治疗手段。本文通过对TBI-IC临床特点、病理生理学机制、治疗策略等进行综述,以为临床诊断与治疗提供理论依据。

关键词: 脑损伤, 创伤性, 血液凝固障碍, 综述

Abstract:

Traumatic brain injury (TBI) often develops secondary coagulopathy (TBI-IC), which is characterized by a hypercoagulable state that leading to intracranial and systemic ischemic events and rapidly developing into a consumptive hypocoagulable state that leading to hemorrhagic injuries. These two coagulative states in patients with TBI are highly integrated and closely associated with poor outcomes. It has become the consensus that early diagnosis and correction of TBI-IC improve survival and neurological outcomes. However, the underlying mechanisms of TBI-IC remain poorly understood, and there is a lack of effective treatment. This article will review the clinical course, potential pathophysiological mechanism and treatment strategy of TBI-IC, hoping to provide reference for better guidance of clinical diagnosis and treatment of TBI-IC.

Key words: Brain injuries, traumatic, Blood coagulation disorders, Review