中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (2): 127-135. doi: 10.3969/j.issn.1672-6731.2020.02.009

• 脑胶质瘤免疫研究进展 • 上一篇    下一篇

2 放射治疗对胶质母细胞瘤免疫状态的影响和意义

聂梦林, 邱晓光   

  1. 100070 首都医科大学附属北京天坛医院放疗科
  • 收稿日期:2020-01-18 出版日期:2020-02-25 发布日期:2020-02-19
  • 通讯作者: 邱晓光,Email:qiuxiaoguang@bjtth.org

The influence of radiotherapy on the immune status of glioblastoma

NIE Meng-lin, QIU Xiao-guang   

  1. Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2020-01-18 Online:2020-02-25 Published:2020-02-19

摘要:

胶质母细胞瘤是成人最常见的脑部恶性肿瘤,预后不良。与其他实体肿瘤相比,胶质母细胞瘤有其特殊的肿瘤免疫学特性,因此靶向免疫检查点细胞程序性死亡蛋白1及其配体(PD1/PDL1)、细胞毒性T淋巴细胞相关抗原4(CTLA-4)在胶质母细胞瘤中的应用尚未明确。对于胶质母细胞瘤这样的免疫“冷肿瘤”而言,放射治疗可以提高其免疫原性,通过从放射治疗影响胶质母细胞瘤微环境、自然杀伤T细胞免疫状态、免疫细胞激活过程这三方面探寻放射治疗支持免疫治疗的证据,以及探讨如何调整放射治疗方案,以达到与免疫治疗配合的最优策略。

关键词: 胶质母细胞瘤, 放射疗法, 免疫, 综述

Abstract:

Glioblastoma (GBM) is the most common adult primary brain tumor and carries a dismal prognosis. Surgery if possible following radiotherapy plus chemotherapy is still a standard first-line therapy due to checkpoint-blocking antibodies targeting programmed cell death protein 1 (PD1)/programmed cell death protein ligand 1 (PDL1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in GBM failed to show the same encouraging results for now. Radiotherapy may serve as a mechanism to improve tumor immunogenicity, especial for a immunologically "cold" tumor like GBM. In this review, we critically evaluate current evidence regarding radiation as an enhancer for immunotherapies through modulation of GBM microenvironment, natural killer T cell (NKT) status, immune processes and how these modulation could optimally argumentation immunotherapy. Insights from radiotherapy may unveil additional novel opportunities to help mobilize immunity against GBM.

Key words: Glioblastoma, Radiotherapy, Immunity, Review