脑肿瘤免疫治疗及转化研究进展

doi:10.3969/j.issn.1672-6731.2020.02.003

摘要/Abstract

摘要：

脑肿瘤预后差且治疗困难，为患者和医疗系统带来巨大负担。目前的标准治疗方案是最大范围手术切除辅助放化疗，尽管免疫治疗已广泛应用于肿瘤的治疗，但是由于中枢神经系统的独立性和肿瘤微环境的特殊性，脑肿瘤免疫治疗仍是亟待研究的重要课题。通过对近期出版并翻译的《脑肿瘤免疫治疗及转化研究》进行概述，全面展示近年该领域的重要成果，在吸取研究经验的同时总结发展趋势，为进一步探索脑肿瘤的免疫治疗提供支持。

关键词: 脑肿瘤, 肿瘤微环境, 免疫疗法, 转化医学研究, 综述

Abstract:

Brain tumors present poor prognosis and high resistance to treatment, bringing devastating burden to patients and the health system. The current standard of care includes surgery with assistant chemoradiotherapy. Due to the independence of the central nervous system as well as the uniqueness of tumor microenvironment (TME), it still warrants further studies in immunotherapy of brain tumors, despite its broad use in other tumors. This article reviewed the recently published and translated Translational Immunotherapy of Brain Tumors and listed the near fundamental results in this field generally. While learning from the experiences from these researches, we also analyzed the current trends in brain immunotherapy, promoting successive explorations in immunotherapy of brain tumors.

Key words: Brian neoplasms, Tumor microenvironment, Immunotherapy, Translational medical research, Review

刘芃昊, 王裕, 马文斌. 脑肿瘤免疫治疗及转化研究进展[J]. 中国现代神经疾病杂志, 2020, 20(2): 79-85.

LIU Peng-hao, WANG Yu, MA Wen-bin. Trends and developments in translational immunotherapy of brain tumors[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(2): 79-85.

http://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I2/79

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