额叶胶质瘤相关癫癎患者白质纤维网络改变研究

doi:10.3969/j.issn.1672-6731.2019.11.009

摘要/Abstract

摘要：

目的探讨额叶胶质瘤相关癫癎（FGRE）患者白质纤维束网络变化特点。方法前瞻性收集2014年1月至2017年12月共13例额叶胶质瘤相关癫癎患者和13例正常对照者，行MRI常规扫描和扩散张量成像（DTI），采用基于纤维束示踪的空间统计学方法（TBSS）观察全脑白质纤维束网络改变。结果与正常对照组相比，FGRE组患者全脑平均扩散率（MD）值显著升高，在3个区块13条白质纤维束中存在显著变化（FWE校正，均P<0.05）；部分各向异性（FA）值变化区域与MD值大致相同，但是差异未达到统计学意义（FWE校正，P>0.05）。结论额叶胶质瘤相关癫癎的发生与肿瘤外区域特定白质纤维束网络改变相关。通过DTI参数和TBSS分析可初步揭示额叶胶质瘤相关癫癎患者早期白质纤维束网络的改变，尤其是MD值可以成为预测癫癎风险的影像学指标。

关键词: 神经胶质瘤, 额叶, 癫癎, 弥散张量成像

Abstract:

Objective To investigate the changes of white matter fiber tracts network in patients with frontal glioma-related epilepsy (FGRE). Methods Thirteen FGRE patients and 13 normal subjects were collected prospectively from January 2014 to December 2017. After collecting the whole brain MRI data, and diffusion tensor imaging (DTI) the tract-based spatial statistics (TBSS) analysis technique was used to find out the characteristics of white matter fiber tracts network changes in the whole brain area of FGRE patients. Results Compared with the normal group, the mean diffusivity (MD) values had significant changes in 3 index, including 13 fiber bundles (FWE correction, P<0.05, for all) in FGRE group. The area of fractional anisotropy (FA) change was roughly the same as MD, but the difference did not reach statistical significance (FWE correction, P>0.05). Conclusions The occurrence of FGRE is associated with changes in specific white matter fiber bundles outside the tumor area. DTI data and TBSS analysis are helpful to reveal the early changes of white matter fiber tracts network in FGRE patients. The change of MD value of corresponding fiber bundle can also be used as an imaging index to predict the risk of preoperative seizure in patients with FGRE.

Key words: Glioma, Frontal lobe, Epilepsy, Diffusion tensor imaging

梁宇超, 周椿尧, 王磊. 额叶胶质瘤相关癫癎患者白质纤维网络改变研究[J]. 中国现代神经疾病杂志, 2019, 19(11): 858-862.

LIANG Yu-chao, ZHOU Chun-yao, WANG Lei. Study on changes of white matter fiber tracts network in patients with frontal glioma-related epilepsy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2019, 19(11): 858-862.

http://journal11.magtechjournal.com/cjcnn/CN/Y2019/V19/I11/858

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Study on changes of white matter fiber tracts network in patients with frontal glioma-related epilepsy

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