中国现代神经疾病杂志 ›› 2019, Vol. 19 ›› Issue (11): 801-806. doi: 10.3969/j.issn.1672-6731.2019.11.002

• 专论 • 上一篇    下一篇

2 脑胶质瘤临床诊断与治疗:积于跬步 蓄势超越

杨学军1, 江涛2   

  1. 1. 300052 天津医科大学总医院神经外科;
    2. 100070 首都医科大学附属北京天坛医院神经外科
  • 收稿日期:2019-11-22 出版日期:2019-11-25 发布日期:2019-11-25
  • 通讯作者: 杨学军,Email:ydenny@126.com
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81872063);国家重点研发计划项目(项目编号:2018YFC0115603);天津医科大学临床医学研究项目(项目编号:2018kylc001)

Clinical diagnosis and treatment of glioma: accumulate small step, ready to surpass

YANG Xue-jun1, JIANG Tao2   

  1. 1 Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China;
    2 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2019-11-22 Online:2019-11-25 Published:2019-11-25
  • Contact: YANG Xue-jun (Email: ydenny@126.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81872063), the National Key Research and Development Program of China (No. 2018YFC0115603), and the Clinical Medical Research Project of Tianjin Medical University (No. 2018kylc001).

摘要:

脑胶质瘤是临床最为常见的原发性中枢神经系统恶性肿瘤,是一种致死性强且预后差的肿瘤。近年来,与脑胶质瘤相关的基础研究、临床诊断与治疗及各种临床试验层出不穷。本文主要对WHO中枢神经系统肿瘤分类第五版可能出现的部分变化进行解读;总结我国脑胶质瘤诊断与治疗指南或规范制定过程中的里程碑事件及存在不足;阐述新型临床试验体系——全球脑胶质母细胞瘤适应性临床创新试验体系(GBM AGILE)对我国精准医疗战略及以科技创新为驱动的医药产业的发展的积极作用。

关键词: 神经胶质瘤, 整合诊断(非MeSH词), 指南, 综述

Abstract:

Glioma is the most common primary central nervous system malignancy, which is a fatal and poorly prognostic tumor. Recent years, basic research, clinical diagnosis and treatment as well as various clinical trials related to glioma have been emerged. This article mainly explains the possible changes in the fifth edition of WHO Central Nervous System Tumor Classification and summarizes both the achievements and shortcomings in the development of the glioma diagnosis and treatment standard in China and also elaborates that the Glioblastoma Multiforme Adaptive Global Innovative Learning Environment (GBM AGILE), a new clinical trial system, plays a positive role in the development of the China's precision medical strategy and the pharmaceutical industry driven by scientific and technological innovation.

Key words: Glioma, Integrated diagnosis (not in MeSH), Guidelines, Review