摘要：

焦虑是帕金森病常见的非运动症状，多见于帕金森病早期，甚至可出现在典型运动症状之前，严重影响帕金森病患者生活质量。结构和功能 MRI 技术通过观察与分析帕金森病伴焦虑患者特定脑皮质与皮质下组织学形态和脑功能的改变，揭示其病理生理学机制，对提高帕金森病伴焦虑的早期诊断具有重要临床意义。 

关键词: 帕金森病, 焦虑, 磁共振成像, 综述

Abstract:

Anxiety is a common non-motor symptom (NMS) of Parkinson's disease (PD). It is mostly seen in the early stage of PD, and can even appear before the typical motor symptoms which severely affects the quality of life of PD patients. Structural and functional MRI technology reveals the pathological and physiological mechanism of PD with anxiety through the cortical and subcortical morphological changes and brain functional changes related to PD with anxiety, which is of great significance to improve the early diagnosis of PD with anxiety.

Key words: Parkinson disease, Anxiety, Magnetic resonance imaging, Review