摘要：

原发性干燥综合征是一种慢性炎症反应性自身免疫性疾病，主要累及外分泌腺，亦可累及神经系统，甚至部分患者以神经系统病变为首发症状。由于目前缺乏原发性干燥综合征合并神经系统病变的统一诊断标准，易误诊和漏诊。本文拟对原发性干燥综合征合并神经系统病变的研究进展和常见临床问题进行概述。

关键词: 干燥综合征, 神经系统, 综述

Abstract:

Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune disease, mainly affecting exocrine glands. Nervous system can also be involved, which can represent the initial manifestation of pSS in some patients. Due to the lack of any uniform diagnostic criteria, pSS is easy to be missed or misdiagnosed. In this review, we provided an in-depth look at clinical manifestations and research hotspots of neurological involvement in pSS.

Key words: Sjogren's syndrome, Nervous system, Review