摘要：

视神经脊髓炎是中枢神经系统炎症性脱髓鞘性疾病，特征性临床表现为严重的视神经炎和横贯性脊髓炎。随着其特异性抗体NMO-IgG 的发现，“视神经脊髓炎”的定义发生巨大变化，此后又提出“视神经脊髓炎谱系疾病”的概念。近年来，我国学者关于视神经脊髓炎/视神经脊髓炎谱系疾病的研究日益增多。本文拟就2010 年以来我国学者在国外杂志发表的关于视神经脊髓炎/视神经脊髓炎谱系疾病的发病机制、NMO-IgG 与疾病关系、诊断与治疗、基因检测等方面进行简要综述。

关键词: 视神经脊髓炎, 水通道蛋白质4, 中国, 综述

Abstract:

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of central nervous system (CNS), characterized by severe optic neuritis (ON) and transverse myelitis (TM). Since the discovery of NMO-immunoglobulin G (NMO-IgG), the definition of NMO has been changed greatly. Later, the concept of "neuromyelitis optica spectrum disorders (NMOSDs)" has been proposed. In recent years, more and more researches done by Chinese researchers were published on international journals. This review will focus on the work about NMO/NMOSDs done by Chinese researchers since 2010, in fields including the pathogenesis, relation between NMO-IgG and NMO/NMOSDs, diagnosis, treatment and gene detection.

Key words: Neuromyelitis optica, Aquaporin 4, China, Review