摘要：

多肽脯氨酰顺反异构酶（Pin1）与多种神经变性病和肿瘤发病有关，特别是在阿尔茨海默病的发生与发展中具有重要作用。Pin1 通过调节tau 蛋白和β-淀粉样前体蛋白磷酸化过程，以及干扰细胞周期以影响阿尔茨海默病的发病。尽管目前大多数学者倾向于Pin1 是神经保护因素，但也有学者认为其可能是促进神经元凋亡的因素，与PIN1 基因多态性相关。因此，Pin1 有可能成为治疗阿尔茨海默病的新靶点，并具备成为早期诊断阿尔茨海默病生物学标记的潜力。

关键词: 肽基脯氨酰异构酶, 阿尔茨海默病, 综述

Abstract:

Peptidyl-prolyl cis/trans isomerase (Pin1) has been identified as an important factor that can affect many neurodegenerative diseases as well as neoplasms. In particular, Pin1 has got a wide attention for its critical function in the occurence and development of Alzheimer's disease (AD). It has been found that Pin1 can affect the incidence of AD by adjusting the phosphorylation of tau and amyloid β-protein precursor (APP), and interfering with the cell cycle. Although a lot of clinical data suggest that Pin1 is a neuroprotective factor, some scholars point out that Pin1 may promote neuronal apoptosis, because of PIN1 gene polymorphism. In summary, Pin1 may become a new target for the treatment of AD, and has the potential to be a biomarker for the early diagnosis of AD.

Key words: Peptidylprolyl isomerase, Alzheimer disease, Review