摘要： 目前难治性癫痫的基因治疗策略主要通过调节神经递质网络、神经肽Y 和神经营养因子等以发挥抗癫痫作用。其中研究较为热门的靶点包括γ-氨基丁酸及其受体、N-甲基-D-天冬氨酸及其受体、甘丙肽、神经肽Y 和神经营养因子等。本文就上述靶点的主要研究结果、各研究的优劣做简要介绍，以为临床解决难治性癫痫提供证据。

关键词: 癫痫, 基因疗法, γ氨基丁酸, N-甲基天冬氨酸, 甘丙肽样肽, 神经肽Y, 神经生长因子类, 综述

Abstract: Nowadays, the strategies of gene therapy for the treatment of refractory epilepsy (RE) mainly include modulating neurotransmitter systems, neuropeptide Y (NPY) and neurotrophic factors. Among them, the hot target spots include γ-aminobutyric acid (GABA) and its receptor, N-methyl-D-aspartate (NMDA) and its receptor, galanin, NPY and neurotrophic factors. This paper reviews the chief research results, and advantages and disadvantages of studies, and provides evidence for the treatment of refractory epilepsy.

Key words: Epilepsy, Gene therapy, Gamma-aminobutyric acid, N-methylaspartate, Galanin-like peptide, Neuropeptide Y, Nerve growth factors, Review