摘要： 目的 探讨MMP-9 及IL-6 与人颈动脉粥样硬化斑块易损性的关系。方法 选择急性脑梗死患者69 例和健康对照者20 例，根据粥样硬化斑块性质分为易损性斑块组和非易损性斑块组，比较两组患者血清MMP-9 和IL-6 水平，并对二者间关系进行相关分析。结果 非易损性斑块组患者血清MMP-9 和IL-6 表达水平高于正常对照组（均P = 0.000），易损性斑块组表达水平高于非易损性斑块组和正常对照组（均P = 0.000），MMP-9 和IL-6 在外周血中的表达变化与斑块易损性呈正相关关系（r = 0.836，P = 0.043）。结论 血清MMP-9 和IL-6 是促进颈动脉粥样硬化斑块易损的重要因素，IL-6 可上调MMP-9的表达水平。

关键词: 动脉粥样硬化, 基质金属蛋白酶-9, 白细胞介素6, 脑梗死

Abstract: Objective To explore the relationship of MMP-9 and IL-6 and the vulnerability of carotid atherosclerotic plaque. Methods According to the plaque vulnerability, 69 patients with acute cerebral infarction were divided into vulnerable plaque group (n = 35) and unvulnerable plaque group (n = 34). Twenty healthy subjects were selected as controls (control group). The levels of serum IL-6 and MMP-9 were examined. Results The level of MMP-9 and IL-6 in the unvulnerable plaque group was significantly higher than that in control group (P = 0.000, for all). The level of MMP-9 and IL-6 in the vulnerable plaque group was higher than that in the unvulnerable plaque group and control group (P = 0.000, for all). A positive correlation was observed between the expression of MMP-9 and IL-6 plaque (r = 0.836, P = 0.043). Conclusion MMP-9 and IL-6 are important factors for the promotion of vulnerable plaque. IL-6 may up-regulate the expression of MMP-9.

Key words: Atherosclerosis, Matrix metalloproteinase 9, Interleukin-6, Brain infarction