Abstract: Pyroptosis is activated caspase-1 trigger special programmed cell. Recent studies have confirmed the pyroptosis in renal cells plays an important role. GSDMD cleavage caspase-1 regulating the downstream inflammatory cytokines maturation、release and triggering inflammation and pyroptosis. From renal inflammatory injury from NLRP3 activation, pyroptosis from GSDMD breakage, the review try to explain the NLRP3－caspase-1-GSDMD drived pyroptosis in renal inflammation injury to explore the essence of kidney inflammatory damage.

Key words: kidney inflammation, pyroptosis, NLRP3，caspase-1, GSDMD