Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 154-158.

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Methodology and application of human physiological reference intervals estimation


  • Received:2020-11-12 Revised:2021-04-01 Online:2022-01-05 Published:2022-01-05
  • Supported by:
    he Key Basic Research Program of the Ministry of Science and Technology of China;Beijing Natural Science Foundation;National Natural Science Foundation of China

Abstract: Establishment of physiological reference intervals (RIs) is important for health status evaluation, disease screening and diagnosis,and the effect assessment of clinical therapy. Currently, there is no review on methodology of RI establishment in China. Therefore, by reviews of literatures on methodology of RI establishment, this study aimed to give a comprehensive description on the purpose and significance of RI establishment and its statistical methods of calculation, as well as its application. Three methods are commonly used for RI calculation: the nonparametric, parametric and robust estimate. Researchers could choose a specific method or methods based on their purpose and the characteristics of the data. This review could provide methodological reference for RI establishment in China, and also guidelines to better understand the meaning of physiological constant RIs in health practices.

Key words: Reference interval, Physiological constants, Methodology, Review