Abstract: Connexin (Cx) is a membrane protein widely found in mammals. Its molecular weight ranges from 26Ku to 56Ku in mammals. connexin 43 (Cx43) is the most widely expressed connexin in mammals and plays an important role in the development and progression of cardiovascular diseases and tumors. In recent years, with the rapid development of molecular imaging, Cx43 as a molecular imaging target may become a new means of cardiovascular disease and tumor diagnosis and treatment.

Key words: Connexin 43（Cx43）, Cardiovascular disease , Tumor , Molecular imaging