Research advances on the age-related macular degeneration

doi:10.16352/j.issn.1001-6325.2024.04.0553

Abstract

Abstract: Age-related macular degeneration(AMD) is a serious threat to the visual health of the elderly, and the dysfunction of retinal pigment epithelial cells(RPE) is a significant etiology risk. Aging process leads to RPE replication senescence, and some environment factors like light exposure and cigarette exposure may lead to RPE stress premature aging, and the decreased lysosomal digestion ability of senescent RPE cells may lead to the accumulation of lipofuscin, triggering the occurrence of early AMD. A series of homeostatic imbalances in aging retina, such as cell senescence-renewal imbalance, oxidative stress-antioxidant imbalance, chronic inflammatory-anti-inflammatory imbalance, intestinal barrier and intestinal microbiota imbalance and pro-angiogenesis-antiangiogenic imbalance all contribute to the development of AMD.

Key words: age-related macular degeneration(AMD), retina, retinal pigment epithelial cells(RPE), cellular senescence

CLC Number:

R774

WEI Dandan, SONG Yuhan, WANG Qi, SU Shulan, ZHU Yue, DUAN Jin'ao. Research advances on the age-related macular degeneration[J]. Basic & Clinical Medicine, 2024, 44(4): 553-557.

References 23

[1]	Barnett BP, Handa JT. Retinal microenvironment imbal-ance in dry age-related macular degeneration: a mini-review[J]. Gerontology, 2013, 59: 297-306.
[2]	Wu DM, Ji XK, Ivanchenko MV, et al. Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa[J]. JCI Insight, 2021, 6: e145029. doi: 10.1172/jci.insight.145029.
[3]	Chen Q, Lin H, Li S, et al. Mini-αA upregulates the miR-155-5p target gene CDK2 and plays an antiapoptotic role in retinal pigment epithelial cells during oxidative stress[J]. J Ophthalmol. 2023, 2023: 6713094. doi: 10.1155/2023/6713094.
[4]	Lee H, Lee HY, Chae JB, et al. Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin[J]. Commun Biol, 2022, 5: 722. doi: 10.1038/s42003-022-03676-3.
[5]	Wang S, Liu Y, Liu Y, et al. Reversed senescence of retinal pigment epithelial cell by coculture with embryonic stem cell via the TGFβ and PI3K pathways[J]. Front Cell Dev Biol, 2020, 8: 588050. doi: 10.3389/fcell.2020.588050.
[6]	Ren J, Ren A, Deng X, et al. Long-chain polyunsatura-ted fatty acids and their metabolites regulate inflammation in age-related macular degeneration[J]. J Inflamm Res. 2022, 15: 865-880.
[7]	Valencia E, García M, Fernández-Vega B, et al. Targeted analysis of tears revealed specific altered metal homeostasis in age-related macular degeneration[J]. Invest Ophthalmol Vis Sci, 2022, 63: 10. doi: 10.1167/iovs.63.4.10.
[8]	Yang M, Tsui MG, Tsang JKW, et al. Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis[J]. Cell Death Dis, 2022, 13: 468. doi: 10.1038/s41419-022-04924-4.
[9]	Orozco LD, Chen HH, Cox C, et al. Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration[J]. Cell Rep, 2020, 30: 1246-1259.
[10]	Liu Y, Bell BA, Song Y, et al. Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload[J]. Aging Cell, 2022, 21: e13579. doi: 10.1111/acel.13579.
[11]	Nashine S, Cohen P, Wan J, et al. Effect of Humanin G(HNG) on inflammation in age-related macular degeneration(AMD)[J]. Aging, 2022, 14: 4247-4269.
[12]	Lin R, Yu J. The role of NAD(+) metabolism in macrophages in age-related macular degeneration[J]. Mech Ageing Dev, 2023, 209: 111755. doi: 10.1016/j.mad.2022.111755.
[13]	Vreones M, Mustapic M, Moaddel R, et al. Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin[J]. Aging cell, 2023, 22: e13754. doi: 10.1111/acel.13754.
[14]	Ren C, Hu C, Wu Y, et al. Nicotinamide mononucleotide ameliorates cellular senescence and inflammation caused by sodium iodate in RPE[J]. Oxid Med Cell Longev, 2022, 2022: 5961123. doi: 10.1155/2022/5961123.
[15]	Lückoff A, Scholz R, Sennlaub F, et al. Comprehensive analysis of mouse retinal mononuclear phagocytes[J]. Nat Protoc, 2017, 12: 1136-1150.
[16]	Datta S, Cano M, Satyanarayana G, et al. Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity[J]. Autophagy, 2022, 19: 1-18.
[17]	Shen G, Li Y, Zeng Y, et al. Kallistatin deficiency induces the oxidative stress-related epithelial-mesenchymal transition of retinal pigment epithelial cells: a novel protagonist in age-related macular degeneration[J]. Invest Ophthalmol Vis Sci, 2023, 64: 15. doi: 10.1167/iovs.64.12.15.
[18]	Blasiak J, Kaarniranta K. Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?[J]. Expert Opin Ther Targets, 2022, 26: 883-895.
[19]	Wang K, Chen YS, Chien HW, et al. Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling[J]. Cell Biosci, 2022, 12: 133. doi: 10.1186/s13578-022-00879-3.
[20]	Scuderi G, Troiani E, Minnella AM. Gut microbiome in retina health: the crucial role of the gut-retina axis[J]. Front Microbiol, 2022, 12: 726792. doi: 10.3389/fmicb.2021.726792.
[21]	Cao YQ, Li YL, Gkerdi A, et al. Association of nutrients, specific dietary patterns, and probiotics with age-related macular degeneration[J]. Curr Med Chem, 2022, 29: 6141-6158.
[22]	Zou GP, Wang T, Xiao JX, et al. Lactate protects against oxidative stress-induced retinal degeneration by activating autophagy[J]. Free Radical Biol Med, 2023, 194: 209-219.
[23]	Abokyi S, To CH, Lam TT, et al. Central role of oxidative stress in age-related macular degeneration: evidence from a review of the molecular mechanisms and animal models[J]. Oxid Med Cell Longev, 2020, 2020: 7901270. doi: 10.1155/2020/7901270.