Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (12): 1925-1929.doi: 10.16352/j.issn.1001-6325.2022.12.1925

• Mini Reviews • Previous Articles     Next Articles

Research progress on the role of bilirubin in inflammatory bowel disease

SHI Li1,2, YUAN Hao2, LIU Min2, ZHENG Ya2, WANG Yu-ping2, GUO Qing-hong2*   

  1. 1. the First Clinical Medical School, Lanzhou University, Lanzhou 730030;
    2. Department of Gastroenterology, Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730030, China
  • Received:2021-07-13 Revised:2021-12-13 Online:2022-12-05 Published:2022-11-23
  • Contact: * guoza@sohu.com

Abstract: The role of bilirubin in inflammatory bowel disease is not only functioned as an antioxidant and anti-inflammatory factor, but also functioned in immune regulation, anti-platelet aggregation, and as inhibition factor of digestive protease and remodeling of microbiota. Serum bilirubin level is correlated with disease activity and severity, so is a potential serum marker of inflammatory bowel disease in terms of supporting clinical diagnosis and treatment of inflammatory bowel disease.

Key words: bilirubin, inflammatory bowel disease, Crohn disease, ulcerative colitis

CLC Number: