Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (12): 1930-1934.doi: 10.16352/j.issn.1001-6325.2022.12.1930

• Mini Reviews • Previous Articles     Next Articles

Research progress of microRNAs as remodelers of lipid metabolic reprogramming in hepatocellular carcinoma

WANG Yu-min1, CHEN Ji-chao1*, WANG Hong-quan2, WANG Jin-hua3, TANG Bo2   

  1. 1. Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049;
    2. Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060;
    3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, CAMS & PUMC, Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050,China
  • Received:2021-05-11 Revised:2021-12-31 Online:2022-12-05 Published:2022-11-23
  • Contact: *

Abstract: Metabolic reprogramming is considered to be one of the top characteristics of tumor cells. Ample experimental studies have shown that microRNAs, which are a group of multifunctional non-coding RNAs, play an important role in the development of hepatocellular carcinoma (HCC) through lipid metabolic reprogramming. The current review briefly introduces the recent progress of specific microRNAs targeting at lipid metabolic reprogramming in HCC, which may provide a potential strategy for clinical targeting tumor therapy.

Key words: hepatocellular carcinoma, microRNAs, lipid metabolic reprogramming, tumorigenesis

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