评估老年衰弱相关血清生物学标志物的研究进展

doi:10.16352/j.issn.1001-6325.2022.04.018

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (4): 646-650.doi: 10.16352/j.issn.1001-6325.2022.04.018

评估老年衰弱相关血清生物学标志物的研究进展

戴靖榕^1,2, 李婕^1,2, 何旭^1,2, 李燕^1,2*

1.昆明理工大学医学院, 云南昆明 650500;
2.云南省第一人民医院老年医学科, 云南昆明 650032

收稿日期:2021-07-28 修回日期:2021-11-11 出版日期:2022-04-05 发布日期:2022-04-01
通讯作者: * liyanken@126.com
基金资助:
国家自然科学基金(81760109);国家重点研发计划(2018YFC2002103);云南省卫生科技计划(2017NS221,2017NS222); 云南省临床医学开发项目(2019LCZXKF-NM08,2021LCZXXF-NM09);云南省老年疾病临床医学研究中心——老年共病治疗及临床转化研究(202102AA310068);云南省董碧蓉专家工作站(202105AF150032)

Research progress on assessment of serum biomarkers related to senile frailty

DAI Jing-rong^1,2, LI Jie^1,2, HE Xu^1,2, LI Yan^1,2*

1. School of Medicine, Kunming University of Science and Technology,Kunming 650500;
2. Department of Geriatrics, the First People's Hospital of Yunnan Province, Kunming 650032,China

Received:2021-07-28 Revised:2021-11-11 Online:2022-04-05 Published:2022-04-01
Contact: * liyanken@126.com

摘要/Abstract

摘要： 当前关于老年衰弱的评估仍然采用量表及问卷形式,这种主观的评估方式易随评估人员及评估量表的不同而产生较大差异,因此,探寻衰弱的客观诊断依据显得尤为重要。随着人群队列和观察性研究的不断展开,老年衰弱在血清学方面取得较大进展。本文主要从血清炎性因子、激素、维生素、同型半胱氨酸及相关蛋白分子对衰弱的影响机制进行综述,为进一步探索老年衰弱的客观诊断依据提供新思路。

关键词: 衰弱, 生物学标志物, 机制, 老年

Abstract: The assessment of senile frailty still implemented with scales and questionnaires. This subjective assessment method is prone to vary greatly with the assessors and scales. Therefore, it is particularly important to explore the Objective diagnosis basis of frailty.With the continuous development of population cohort and observational studies, great progress has been made in the serology of senile frailty.This article mainly reviews the influence mechanism of serum inflammatory factors, hormones, vitamins, homocysteine and related protein molecules on frailty and provides new ideas to further exploring the Objective diagnosis basis of frailty in the elderly.

Key words: frailty, biological markers, mechanism, aged

中图分类号:

R592

戴靖榕, 李婕, 何旭, 李燕. 评估老年衰弱相关血清生物学标志物的研究进展[J]. 基础医学与临床, 2022, 42(4): 646-650.

DAI Jing-rong, LI Jie, HE Xu, LI Yan. Research progress on assessment of serum biomarkers related to senile frailty[J]. Basic & Clinical Medicine, 2022, 42(4): 646-650.

参考文献

[1] Hoogendijk EO, Afilalo J, Ensrud KE, et al. Frailty: implications for clinical practice and public health[J]. Lancet,2019,394:1365-1375.
[2] Barsony J, Kleess L, Verbalis JG. Hyponatremia is linked to bone loss, osteoporosis, fragility and bone fractures[J]. Front Horm Res, 2019,52:49-60.
[3] 吴炎,边瓯,马宁,等.老年住院患者血钠水平与衰弱相关性研究[J].临床军医杂志,2020,48:149-151,154.
[4] Aranda-Gallardo M, Gonzalez-Lozano A, Oña-Gil JI, et al. Relation between hyponatraemia and falls by acute hospitalised patients: a case-control study[J]. J Clin Nurs, 2021. doi:10.1111/jocn.15952.
[5] Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis[J]. Ageing Res Rev, 2016,31:1-8.
[6] Mehta M, Louissaint J, Parikh NS, et al. Cognitive function, sarcopenia, and inflammation are strongly associated with frailty: a framingham cohort study[J]. Am J Med,2021. doi:10.1016/j.amjmed.2021.07.012.
[7] Tembo MC, Holloway-Kew KL, Bortolasci CC, et al. Association between serum interleukin-6 and frailty in older men: cross-sectional data[J]. Eur Geriatr Med, 2021,12:887-892.
[8] Hsu PF, Pan WH, Yip BS, et al. C-reactive protein predicts incidence of dementia in an elderly asian community cohort[J]. J Am Med Dir Assoc,2017,18:277.doi:10.1016/j.jamda.2016.12.006.
[9] Wimalawansa SJ, Razzaque MS, Al-Daghri NM. Calcium and vitamin D in human health: Hype or real?[J]. J Steroid Biochem Mol Biol,2018,180:4-14.
[10] 戴靖榕,李婕,何旭. 住院老年患者25-羟维生素D及白介素6与衰弱的相关性研究[J]. 中国全科医学,2021. doi:10.12114/j.issn.1007-9572.2021.02.037.
[11] Kitsu T, Kabasawa K, Ito Y, et al. Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population[J]. J Bone Miner Metab, 2020,38:198-204.
[12] Remelli F, Vitali A, Zurlo A, et al . Vitamin D deficiency and sarcopenia in older persons[J]. Nutrients,2019,11:28-61. doi:10.3390/nu11122861.
[13] Haren MT, Siddiqui AM, Armbrecht HJ, et al. Testosterone modulates gene expression pathways regulating nutri-ent accumulation, glucose metabolism and protein turn-over in mouse skeletal muscle[J]. Int J Androl, 2011,34:55-68.
[14] Yeap BB, Alfonso H, Chubb SAP, et al. U-Shaped association of plasma testosterone, and no association of plasma estradiol, with incidence of fractures in men[J]. J Clin Endocrinol Metab,2020,105:dgaa115. doi:10.1210/clinem/dgaa115.
[15] Ahmed M, Shaikh A, Fida M. Diagnostic performance of various cephalometric parameters for the assessment of vertical growth pattern[J]. Dental Press J Orthod,2016,21:41-49.
[16] Ikeda K, Horie-Inoue K, Inoue S. Functions of estrogen and estrogen receptor signaling on skeletal muscle[J]. J Steroid Biochem Mol Biol,2019.doi:10.1016/j.jsbmb.2019.105375.
[17] Carcaillon L, García-García FJ, Tresguerres JA, et al. Higher levels of endogenous estradiol are associated with frailty in postmenopausal women from the toledo study for healthy aging[J]. J Clin Endocrinol Metab, 2012,97:2898-2906.
[18] Soni RM, Tiwari SC, Mahdi AA, et al. Serum homocysteine and behavioral and psychological symptoms of dementia: Is there any correlation in alzheimer's disease?[J]. Ann Neurosci, 2019,25:152-159.
[19] Ruan Y, Guo Y, Kowal P, et al. Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China[J]. BMC Geriatr,2019,19:327-340.
[20] 张佳佳,王丽.老年2型糖尿病病人糖脂代谢指标与衰弱程度的相关性研究[J]. 实用老年医学,2020,4:344-347.
[21] Zaslavsky O, Walker RL, Crane PK, et al. Glucose levels and risk of frailty[J]. Gerontol A Biol Sci Med Sci, 2016,71:1223-1229.
[22] Hamada S, Gulliford MC. Mortality in individuals aged 80 and older with type 2 diabetes mellitus in relation to glycosylated hemoglobin, blood pressure, and total cholesterol[J]. J Am Geriatr Soc, 2016,64:1425-1431.
[23] Mailliez A, Guilbaud A, Puisieux F, et al. Circulating biomarkers characterizing physical frailty: CRP, hemoglobin, albumin, 25OHD and free testosterone as best biomarkers. Results of a meta-analysis[J]. Exp Gerontol,2020. doi:10.1016/j.exger.2020.111014.
[24] Yang L, Smith L, Hamer M. Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing[J]. J Epidemiol Community Health, 2019,73:86-88.

评估老年衰弱相关血清生物学标志物的研究进展

Research progress on assessment of serum biomarkers related to senile frailty

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	林柏柏, 钱风华, 钱义明, 赵雷, 孙旗, 褚梦瑶, 沈梦雯. 脓毒症并发毛细血管渗漏综合征的研究进展[J]. 基础医学与临床, 2022, 42(7): 1144-1147.
[2]	赵肖灵, 何润之, 孙玉姣, 张小冲, 杨林芳, 王瑞, 程芳. 活动期白癜风患者血清γ干扰素含量升高[J]. 基础医学与临床, 2022, 42(7): 1067-1070.
[3]	任海强, 李雷, 杨旺燕, 杜鹃, 姜丹丹, 闫莉, 傅润乔. 小剂量艾司氯胺酮联合右美托咪定在老年患者椎体成形术麻醉中的应用[J]. 基础医学与临床, 2022, 42(6): 950-954.
[4]	刘延丽, 赵瑞雪, 潘燕, 马雅军, 赵暾, 蒋晓燕, 李淑娟. 抑郁症状增加中国老年人跌倒风险[J]. 基础医学与临床, 2022, 42(6): 945-949.
[5]	努尔曼·阿卜杜克力木, 韩正风, 马艳. 医院-社区-家庭一体化康复模式对老年衰弱综合征患者的影响[J]. 基础医学与临床, 2022, 42(4): 640-645.
[6]	武国智, 安丽娜, 刘敏, 王玉平, 郭庆红. 雌激素及其受体在克罗恩病发生和发展中作用的研究进展[J]. 基础医学与临床, 2022, 42(3): 494-497.
[7]	袁景林, 马雅军, 李晓东, 蒋晓燕, 王笑峰, 李淑娟, 周晓梅. 认知衰弱增加老年人群5年后的跌倒风险[J]. 基础医学与临床, 2022, 42(2): 201-207.
[8]	杨溢铎, 国海东, 邵水金, 刘玉璞. 雪旺细胞促进周围神经再生机制的研究进展[J]. 基础医学与临床, 2022, 42(1): 145-148.
[9]	张杨孙弯弯陆丽丹冯晓玲. 细胞自噬与凋亡相互作用分子机制的研究进展[J]. 基础医学与临床, 2021, 41(9): 1342-1346.
[10]	袁景林赵瑞雪李晓东蒋晓燕王笑峰周晓梅李淑娟. 运动认知风险综合征增加老年人住院风险[J]. 基础医学与临床, 2021, 41(8): 1169-1173.
[11]	王行行王导新. NETs与急性呼吸窘迫综合征的研究进展[J]. 基础医学与临床, 2021, 41(7): 1047-1051.
[12]	郭希, 赖莘秀, 杨媚滟, 李峤桢, 王思行, 宋章永. 抑制侵袭性真菌的新型分子及其作用靶点研究进展[J]. 基础医学与临床, 2021, 41(6): 904-908.
[13]	赵瑞雪, 马雅军, 刘惠, 李晓东, 王笑峰, 蒋晓燕, 李淑娟. 认知衰弱诊治的研究进展[J]. 基础医学与临床, 2021, 41(6): 895-898.
[14]	赵平平, 刘靖芳. 假性甲状旁腺功能减退症的临床特点和分子遗传学机制研究进展[J]. 基础医学与临床, 2021, 41(4): 584-588.
[15]	杨晶晶, 陈嘉屿. 肠道微生物失衡在慢性便秘中作用的研究进展[J]. 基础医学与临床, 2021, 41(4): 593-597.