血小板微粒促进动脉粥样硬化发生的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (11): 1551-1555.

血小板微粒促进动脉粥样硬化发生的研究进展

郭方君, 杨人强^*

南昌大学第二附属医院心血管内科, 江西南昌 330000

收稿日期:2020-04-08 修回日期:2020-06-28 出版日期:2020-11-05 发布日期:2020-10-30
通讯作者: ^* yangrenqiangcn@163.com
基金资助:
国家自然科学基金(81960081)

Research progress on the role of platelet-derived microparticles in the development of atherosclerosis

GUO Fang-jun, YANG Ren-qiang^*

Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, China

Received:2020-04-08 Revised:2020-06-28 Online:2020-11-05 Published:2020-10-30
Contact: ^* yangrenqiangcn@163.com

摘要/Abstract

摘要： 血小板微粒(PMPs)是由血小板释放的直径极小的囊泡,其结构组成复杂,含有蛋白质、mRNAs、miRNAs等生物活性物质,参与机体多种病理生理过程。PMPs通过参与血管内皮细胞损伤、炎性反应、脂蛋白沉积、巨噬细胞吞噬及斑块不稳定过程,促进动脉粥样硬化(AS)的发生发展,抗血小板药物可降低PMPs的血浆水平。因此,PMPs为心血管疾病的发病机制及治疗提供了新视角。

关键词: 血小板微粒, 动脉粥样硬化, 内皮细胞, 炎性反应

Abstract: Platelet-derived microparticles(PMPs) are extremely small vesicles with complex structure and composition released by platelets, which contain proteins, mRNAs, miRNAs and other bioactive substances and participate in various pathophysiological processes. PMPs promote the development of atherosclerosis(AS) by participating in the processes of vascular endothelial cell injury, inflammatory reaction, lipoprotein deposition, macrophage phagocytosis and plaque instability. Anti-platelet drugs can lower down the plasma level of PMPs. Therefore, PMPs provide a new perspective for the explanation of the pathogenesis and treatment of cardiovascular diseases.

Key words: platelet-derived microparticles, atherosclerosis, endothelial cells, inflammatory reaction

中图分类号:

R541.4

郭方君, 杨人强. 血小板微粒促进动脉粥样硬化发生的研究进展[J]. 基础医学与临床, 2020, 40(11): 1551-1555.

GUO Fang-jun, YANG Ren-qiang. Research progress on the role of platelet-derived microparticles in the development of atherosclerosis[J]. Basic & Clinical Medicine, 2020, 40(11): 1551-1555.

参考文献

[1] Uveges A, Jenei C, Kiss T, et al. Three-dimensional evaluation of the spatial morphology of stented coronary artery segments in relation to restenosis[J]. Int J Cardiovasc Imaging, 2019, 35: 1755-1763.
[2] Alarcon M. Generation of platelet-derived microparticles through the activation of the toll-like receptor 4[J]. Heliyon, 2019, 5: e01486. doi: 10.1016/j.heliyon.2019.e01486.
[3] De Paoli SH, Tegegn TZ, Elhelu OK, et al. Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome[J]. Cell Mol Life Sci, 2018, 75: 3781-3801.
[4] Ponomareva AA, Nevzorova TA, Mordakhanova ER, et al. Intracellular origin and ultrastructure of platelet-deri-ved microparticles[J]. J Thromb Haemost, 2017, 15: 1655-1667.
[5] Anene C, Graham AM, Boyne J, et al. Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864: 2633-2643.
[6] Mortberg J, Lundwall K, Mobarrez F, et al. Increased concentrations of platelet-and endothelial-derived microparticles in patients with myocardial infarction and reduced renal function-a descriptive study[J]. BMC Nephrol, 2019, 20: 71. doi: 10.1186/s12882-019-1261-x.
[7] Gomes J, Lucien F, Cooper TT, et al. Analytical considerations in nanoscale flow cytometry of extracellular vesi-cles to achieve data linearity[J]. Thromb Haemost, 2018, 118: 1612-1624.
[8] Nielsen T, Kristensen SR, Gregersen H, et al. Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma[J]. PLoS One, 2019, 14: e0210835. doi: 10.1371/journal.pone.0210835.
[9] Onodi Z, Pelyhe C, Terezia Nagy C, et al. Isolation of high-purity extracellular vesicles by the combination of iodixanol density gradient ultracentrifugation and bind-elute chromatography from blood plasma[J]. Front Physiol, 2018, 9: 1479. doi: 10.3389/fphys.2018.01479.
[10] Zacharia E, Antonopoulos AS, Oikonomou E, et al. Plasma signature of apoptotic microvesicles is associated with endothelial dysfunction and plaque rupture in acute coronary syndromes[J]. J Mol Cell Cardiol, 2020, 138: 110-114.
[11] Wang GH, Ma KL, Zhang Y, et al. Platelet micro-particles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway[J]. Acta Pharmacol Sin, 2019, 40: 468-476.
[12] Kong L, Li K, Gao L, et al. Mediating effects of platelet-derived extracellular vesicles on PM2.5-induced vascular endothelial injury[J]. Ecotoxicol Environ Saf, 2020, 198: 110652. doi: 10.1016/j.ecoenv.2020.110652.
[13] Kuravi SJ, Harrison P, Rainger GE, et al. Ability of platelet-derived extracellular vesicles to promote neutrophil-endothelial cell interactions[J]. Inflammation, 2019, 42: 290-305.
[14] Vajen T, Benedikter BJ, Heinzmann ACA, et al. Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype[J]. J Extracell Vesicles, 2017, 6: 1322454. doi: 10.1080/20013078.2017.1322454.
[15] Chatterjee M, Rath D, Schlotterbeck J, et al. Regulation of oxidized platelet lipidome: implications for coronary artery disease[J]. Eur Heart J, 2017, 38: 1993-2005.
[16] Diehl P, Nienaber F, Zaldivia MTK, et al. Lysophosphatidylcholine is a major component of platelet microvesicles promoting platelet activation and reporting atherosclerotic plaque instability[J]. Thromb Haemost, 2019, 119: 1295-1310.
[17] Vasina EM, Cauwenberghs S, Feijge MA, et al. Microparticles from apoptotic platelets promote resident macrophage differentiation[J]. Cell Death Dis, 2011, 2: e211. doi: 10.1038/cddis.2011.94.
[18] Feng C, Chen Q, Fan M, et al. Platelet-derived microparticles promote phagocytosis of oxidized low-density lipoprotein by macrophages, potentially enhancing foam cell formation[J]. Ann Transl Med, 2019, 7: 477. doi: 10.21037/atm.2019.08.06.
[19] Laffont B, Corduan A, Rousseau M, et al. Platelet microparticles reprogram macrophage gene expression and function[J]. Thromb Haemost, 2016, 115: 311-323.
[20] 汪泽扬, 潘丽娜, 陈丽媛,等. 血小板微粒对ApoE~(-/-)小鼠动脉粥样硬化斑块形成及稳定性的影响[J]. 第三军医大学学报, 2019, 41: 514-520.
[21] Recabarren-Leiva D, Alarcon M. Standardization of a fast and effective method for the generation and detection of platelet-derived microparticles by a flow cytometer[J]. Immunol Lett, 2018, 194: 79-84.
[22] Geng XY, Xiao N, Han Y, et al. Platelet microparticles: A tool to predict infarction area in rats[J]. J Invest Surg, 2019, 1-6. doi: 10.1080/08941939.2019.1606369.
[23] Rosinska J, Ambrosius W, Maciejewska J, et al. Association of platelet-derived microvesicles and their phenotypes with carotid atherosclerosis and recurrent vascular events in patients after ischemic stroke[J]. Thromb Res, 2019, 176: 18-26.
[24] Xue LJ, Cui BB, Li X, et al. Association of elevated platelet microparticles with disease activity in rheumatoid arthritis[J]. J Sichuan University(Medicial Science Edition), 2017, 48: 405-409.
[25] Miao D, Ma TT, Chen M, et al. Platelets release proinflammatory microparticles in anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Rheumatology (Oxford), 2019, doi: 10.1093/rheumatology/kez044.