单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2022.02.019

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (2): 335-339.doi: 10.16352/j.issn.1001-6325.2022.02.019

单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

郭梦然^1,2, 闵行^1,2, 叶月^1,2, 许晓双^1,2, 甄东户^2*

1.兰州大学第一临床医学院内分泌科, 甘肃兰州 730030;
2.兰州大学第一医院内分泌科, 甘肃兰州 730030

收稿日期:2020-10-13 修回日期:2021-01-04 发布日期:2022-01-24
通讯作者: ^* zhdh8279@163.com
基金资助:
中央高校基本科研业务费专项资金重点项目(2022142zrk012);标准化代谢性疾病管理中心专项研究基金(2018-mmczxjj-3);甘肃省自然科学基金资助(18JR3RA314)

Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease

GUO Meng-ran^1,2, MIN Hang^1,2, YE Yue^1,2, XU Xiao-shuang^1,2, ZHEN Dong-hu^2*

1. Department of Endocrinology, the First College of Clinical Medicine, Lanzhou University, Lanzhou 730030;
2. Department of Endocrinology, the First Hospital of Lanzhou University,Lanzhou 730030, China

Received:2020-10-13 Revised:2021-01-04 Published:2022-01-24
Contact: ^* zhdh8279@163.com

摘要/Abstract

摘要： 糖尿病肾脏疾病具有很明显的家族聚集性及种族差异,已经确定了一些与糖尿病肾脏疾病易感性有关的单核苷酸多态性(SNPs),尤其是吞噬和细胞运动性1基因(ELMO1)和氯化钠共转运蛋白基因(SLC12A3),与中国人群糖尿病肾脏疾病发展进展有关;同时炎性反应在糖尿病肾脏疾病的发生和发展中起着关键作用,其中细胞和2型固有淋巴细胞(ILC2)分泌炎性因子促进肾脏慢性炎性反应及纤维化。

关键词: 糖尿病肾脏疾病, 单核苷酸多态性, 慢性炎性反应

Abstract: Diabetic kidney disease has obvious family aggregation and ethnic differences, some single nucleotide polymorphisms (SNPs) related to the susceptibility of diabetic kidney disease have been identified, especially engulfment and cell motility 1 (ELMO1) and solute carrier family 12 member 3(SLC12A3), which are related to the development of diabetic kidney disease in Chinese population. Meanwhile, inflammation plays a key role in the occurrence and development of diabetic kidney disease, including T cell and type-2 innate lymphoid cell(ILC2) promote chronic inflammatory response and fibrosis of kidney by secreting inflammatory factors.

Key words: diabetic kidney disease, the single nucleotide polymorphisms, chronic inflammatory reaction

中图分类号:

郭梦然, 闵行, 叶月, 许晓双, 甄东户. 单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展[J]. 基础医学与临床, 2022, 42(2): 335-339.

GUO Meng-ran, MIN Hang, YE Yue, XU Xiao-shuang, ZHEN Dong-hu. Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease[J]. Basic & Clinical Medicine, 2022, 42(2): 335-339.

参考文献

[1]中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志,2018,38:292-344.
[2]刘国强,谢超,洪天配. 美国临床内分泌医师协会2015年版糖尿病综合管理临床实践指南的解读[J]. 糖尿病天地(临床),2016,10:146-149.
[3]Tziastoudi M, Stefanidis I, Zintzaras E. The genetic map of diabetic nephropathy: evidence from a systematic review and meta-analysis of genetic association studies[J]. Clin Kidney J, 2020, 13:768-781.
[4]Hathaway CK, Chang AS, Grant R, et al. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy[J]. Proc Natl Acad Sci U S A, 2016, 113:2218-2222.
[5]Mehrabzadeh M, Pasalar P, Karimi M, et al. Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population[J]. J Diabetes Metab Disord, 2015, 15:43.doi:10.1186/s40200-016-0265-3.
[6]Bodhini D, Chidambaram M, Liju S, et al. Association of rs11643718 SLC12A3 and rs741301 ELMO1 variants with diabetic nephropathy in south indian population[J]. Ann Hum Genet, 2016, 80:336-341.
[7]Yahya MJ, Ismail PB, Nordin NB, et al. Association of CCL2, CCR5, ELMO1, and IL8 polymorphism with diabetic nephropathy in malaysian type 2 diabetic patients[J]. Int J Chronic Dis, 2019, 2019:2053015.doi:10.1155/2019/2053015.
[8]Hou Y, Gao Y, Zhang Y, et al. Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population[J]. Diabetol Metab Syndr, 2019, 11:97.doi:10.1186/s13098-019-0492-0.
[9]An C, Liang J, Zhang K, et al. Polymorphisms in the SLC12A3 gene encoding sodium-chloride cotransporter are associated with hypertension: a family-based study in the mongolian population[J]. Kidney Blood Press Res, 2016, 41:18-28.
[10]De La Cruz-Cano E, Jiménez-González CDC, Morales-García V, et al. Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review[J]. BMC Nephrol, 2019, 20:393.doi:10.1196/s12882-019-1590-9.
[11]Abu Seman N, He B, Ojala JR, et al. Genetic and biological effects of sodium-chloride cotransporter (SLC12A3) in diabetic nephropathy[J]. Am J Nephrol, 2014, 40:408-416.
[12]Zhang R, Zhuang L, Li M, et al. Arg913Gln of SLC12A3 gene promotes development and progression of end-stage renal disease in Chinese type 2 diabetes mellitus[J]. Mol Cell Biochem, 2018, 437:203-210.
[13]Hickey FB, Martin F. Role of the immune system in diabetic kidney disease[J]. Curr Diab Rep, 2018, 18:20.doi:org/10.1007/s11892-018-0984-6.
[14]Tang PC, Zhang YY, Chan MK, et al. The emerging role of innate immunity in chronic kidney diseases[J]. Int J Mol Sci, 2020, 21.doi:10.3390/ijms21114018.
[15]Araújo LS, Torquato BGS, Da Silva CA, et al. Renal expression of cytokines and chemokines in diabetic nephropathy[J]. BMC Nephrol, 2020, 21:308. doi:10.1186/s12882-020-01960-0.
[16]Ma C, Greten TF. Commensal bacteria (ab)use CD8(+) T cells to induce insulin resistance[J]. Sci Immunol, 2017, 2.doi:10.1126/sciimmunol.aan1473.
[17]Zhang N, Tai J, Qu Z, et al. Increased CD4(+)CXCR5(+)T follicular helper cells in diabetic nephropathy[J]. Autoimmunity, 2016, 49:405-413.
[18]Abouzeid S, Sherif N. Role of alteration in Treg/Th17 cells' balance in nephropathic patients with Type 2 diabetes mellitus[J]. Electron Physician, 2015, 7:1613-1618.
[19]Ebbo M, Crinier A, Vély F, et al. Innate lymphoid cells: major players in inflammatory diseases[J]. Nat Rev Immunol, 2017, 17:665-678.
[20]Kato A. Group 2 innate lymphoid cells in airway diseases[J]. Chest, 2019, 156:141-149.
[21]Mikami Y, Takada Y, Hagihara Y, et al. Innate lymphoid cells in organ fibrosis[J]. Cytokine Growth Factor Rev, 2018, 42:27-36.
[22]Cao Q, Wang Y, Niu Z, et al. Potentiating tissue-resident type 2 innate lymphoid cells by IL-33 to prevent renal ischemia-reperfusion injury[J]. J Am Soc Nephrol, 2018, 29:961-976.
[23]Kabata H, Moro K, Koyasu S. The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms[J]. Immunol Rev, 2018, 286:37-52.
[24]邱书娟,孙秀菊,李香玲.银杏叶提取物减轻糖尿病大鼠肾缺血再灌注损伤[J].基础医学与临床,2019,39:1729-1734.
[25]路萍,徐芸芸,苏兆亮.糖尿病肾病患者Ⅱ型固有淋巴细胞活性增强参与代谢综合征的组分聚集状态形成[J].细胞与分子免疫学杂志, 2017, 33:820-825.
[26]Liu C, Qin L, Ding J, et al. Group 2 innate lymphoid cells participate in renal fibrosis in diabetic kidney disease partly via TGF-β1 signal pathway[J]. J Diabetes Res, 2019, 2019:8512028.doi:10.1155/2019/8512028.

单核苷酸多态性和免疫细胞在糖尿病肾脏疾病中的研究进展

Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease

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