肠道菌群和“肠-肺”轴在脓毒症中的作用

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (8): 1109-1112.

肠道菌群和“肠-肺”轴在脓毒症中的作用

邵瑞飞¹, 杨艳¹, 郑志榕², 赵世民², 陈国兵^1,2*

1.昆明理工大学医学院, 云南昆明 650500;
2.云南省第一人民医院重症医学科, 云南昆明 650032

收稿日期:2019-10-21 修回日期:2020-01-18 出版日期:2020-08-05 发布日期:2020-07-29
通讯作者: ^*rocktom38chen@163.com
基金资助:
国家自然科学基金(81660316);云南省应用基础研究(昆医联合专项)[2017FE467(-121)];云南省医学学科后备人才项目(H-2017059);云南省临床医学中心开放项目(2019LCZXKF-HX04)

Function of gut microbiota and “gut-lung” axis in sepsis

SHAO Rui-fei¹, YANG Yan¹, ZHENG Zhi-rong², ZHAO Shi-min², CHEN Guo-bing^1,2*

1. Medical School, Kunming University of Science and Technology, Kunming 650500;
2. Department of Critical Medicine, the First People' s Hospital of Yunnan Province, Kunming 650032, China

Received:2019-10-21 Revised:2020-01-18 Online:2020-08-05 Published:2020-07-29
Contact: ^*rocktom38chen@163.com

摘要/Abstract

摘要： 肠道菌群是寄生在人体肠道内数量庞杂的微生物群。“肠-肺”轴是连接肠道和肺部的双向轴。肠道菌群和“肠-肺”轴参与了脓毒症的发生与发展。脓毒症发生时,肠黏膜屏障受损,肠道菌群失调,细菌移位,肺为最先发生损伤的器官,肺部感染也会导致肠道功能紊乱。

关键词: 肠道菌群, “肠-肺”轴, 细菌移位, 脓毒症

Abstract: Gut microbiota is a large number of microorganisms that colonized in human intestinal tract. The “gut lung” axis is a two-way axis connecting the intestine and the lung. Gut microbiota and “gut lung” axis are involved in the occurrence and development of sepsis. When sepsis occurs, the gut mucosal barrier is damaged, the gut microbiota is imbalance, and bacterial translocation occurs. The lung is the first organ to be effected, and the pulmonary infection may lead to intestinal dysfunction.

Key words: gut microbiota, “gut-lung” axis, bacterial translocation, sepsis

中图分类号:

邵瑞飞, 杨艳, 郑志榕, 赵世民, 陈国兵. 肠道菌群和“肠-肺”轴在脓毒症中的作用[J]. 基础医学与临床, 2020, 40(8): 1109-1112.

SHAO Rui-fei, YANG Yan, ZHENG Zhi-rong, ZHAO Shi-min, CHEN Guo-bing. Function of gut microbiota and “gut-lung” axis in sepsis[J]. Basic & Clinical Medicine, 2020, 40(8): 1109-1112.

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