基础医学与临床 ›› 2018, Vol. 38 ›› Issue (11): 1595-1598.

• 疑难病例 • 上一篇    下一篇

一例2型糖尿病患者24 h尿蛋白定量结果的分析

侯立安1,孙巧玲2,王立3,苏薇4,张俊保4,嵇巍4,秦绪珍1   

  1. 1. 中国医学科学院北京协和医院
    2. 山东大学齐鲁医院
    3. 北京协和医院
    4. 北京协和医院检验科
  • 收稿日期:2017-09-28 修回日期:2017-12-29 出版日期:2018-11-05 发布日期:2018-11-22
  • 通讯作者: 秦绪珍 E-mail:qxz_01@163.com

Results interpretation of 24 hours urinary protein in a patient with type 2 diabetes mellitus

  • Received:2017-09-28 Revised:2017-12-29 Online:2018-11-05 Published:2018-11-22
  • Contact: Xuzhen Qin E-mail:qxz_01@163.com

摘要: 目的 探讨24 h尿蛋白定量结果的临床判读。方法 通过结合尿常规、尿沉渣和尿蛋白电泳结果,分析一例2型糖尿病患者在留置导尿管和未留置导尿管期间,24 h尿蛋白定量结果的变化。结果 患者24 h尿蛋白检测结果的变化与留置导尿管没有必然联系。该患者24 h尿蛋白检测结果阳性时,尿蛋白电泳显示尿蛋白成分复杂,多次检出α2巨球蛋白,提示患者尿蛋白来自于肾后性疾病;尿常规和尿沉渣检测结果显示存在大量细菌和红白细胞,提示患者存在感染,导致尿蛋白定量结果假阳性。结论 解读24 h尿蛋白定量结果时,应注意结合尿常规、尿沉渣和尿蛋白电泳具体判断尿蛋白的来源。

关键词: 24小时尿蛋白定量

Abstract: Objective To explore the interpretation of 24h urinary protein. Method By combination of urine routine, urine sediment and urine protein electrophoresis, the results of 24h urinary protein in a type 2 diabetic mellitus (DM2) patient were analyzed in the condition with and without a catheter. Result There’s no association between 24h urinary protein and catheter indwelling. When 24h urinary protein was positive, urine electrophoresis showed the components of urine protein are complex and presentα2 macroglobulin suggested the source of urine protein from post-renal diseases. In the urine routine and urine sediment tests lots of bacteria, blood cells and white cells were detected, which implied the patients suffering with urinary infection and caused the false positive results of 24h urine protein. Conclusion When the results of 24 h urine protein were interpreted, clinicians should combine urine routine, urine sediment and urine protein electrophoresis to give a comprehensive judgement for the source of urine protein.

Key words: 24-hour urine protein examination