基础医学与临床 ›› 2016, Vol. 36 ›› Issue (2): 267-271.
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易红,张政
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Hong YI1,易红
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摘要： 长链非编码RNA（lncRNA）与微小RNA（miRNA）之间存在相互调控关系。lncRNA可作为一种竞争性内源性RNA（ceRNA）与miRNA相互作用，参与靶基因的表达调控，反之，miRNA可通过RNA诱导沉默复合物（RISC）调控lncRNA发挥生物学功能，两者共同参与多种疾病的发生。
关键词: 长链非编码RNA, 微小RNA, 相互作用, 疾病
Abstract: There is a interaction between long con-coding RNA(lncRNA) and microRNA(miRNA). lncRNA can interact with the miRNA as a competing endogenous RNA(ceRNA) to participate in the expression regulation of target genes. Whereas miRNA can regulate lncRNA to exert biological functions by RNA-inducde silencing complex(RISC). The interaction between lncRNA and miRNA participates in the occurrence of various diseases together. Now this paper summarizes the influence of interaction between lncRNA and miRNA on disease.
Key words: lncRNA, microRNA, interactions, diseases
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中文分类号：R394.3
易红 张政. lncRNA与miRNA相互作用对疾病的影响[J]. 基础医学与临床, 2016, 36(2): 267-271.
Hong YI 易红. The influence of interaction between lncRNA and miRNA on disease[J]. Basic & Clinical Medicine, 2016, 36(2): 267-271.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2016/V36/I2/267
