基础医学与临床 ›› 2016, Vol. 36 ›› Issue (2): 262-266.
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沈天允,史志周
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摘要： 肉碱棕榈酰转移酶1（CPT1）是肝脏组织细胞中长链脂肪酸β-氧化的关键调节酶和限速酶。其亚型CPT1A和CPT1C能够促进肿瘤的生长。CPT1A在胶质母细胞瘤、淋巴瘤、食管癌和乳腺癌等多种恶性肿瘤中扩增且高表达，抑制CPT1A活性和表达的药物具有明显的抗肿瘤作用。因此CPT1在肿瘤癌变中具有重要促进作用，可能成为肿瘤诊断的分子标志物和抗肿瘤治疗的新靶点。
关键词: CPT1, β-氧化, 恶性肿瘤, 肿瘤癌变
Abstract: Carnitine palmitoyltransferase 1 (CPT1) is the key and rate-limiting enzyme of long chain fatty acids β-oxidation in liver cells. CPT1A and CPT1C are subtypes of CPT1 which can promote tumor growth. CPT1A was overexpressed and amplificated in glioblastoma, lymphoma, esophageal cancer and breast cancer. The drugs which could inhibit the activity or expression of CPT1A had anti-tumor effects. Therefore, CPT1 has roles in promoting the tumorigenesis, and it may develop into an molecular biomarker and a new target for cancer therapy.
Key words: CPT1, β-oxidation, malignant tumor, tumorigenesis
中图分类号:
R34
沈天允 史志周. CPT1基因在肿瘤中的研究进展[J]. 基础医学与临床, 2016, 36(2): 262-266.
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https://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2016/V36/I2/262
