SUMO化修饰及其对信号通路的调控

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (4): 578-583.

SUMO化修饰及其对信号通路的调控

肖云飞, 王嘉宾, 耿海刚, 刘青娟^*

河北医科大学基础医学院病理学教研室河北省肾脏病重点实验室, 河北石家庄 050017

收稿日期:2020-04-16 修回日期:2020-07-27 出版日期:2021-04-05 发布日期:2021-04-05
通讯作者: ^*liuqj246@163.com
基金资助:
国家自然科学基金青年科学基金(81600564)

SUMO modification and its regulation of signaling pathways

XIAO Yun-fei, WANG Jia-bin, GENG Hai-gang, LIU Qing-juan^*

Key Laboratory of Nephrology of Hebei Province, Department of Pathology,College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017,China

Received:2020-04-16 Revised:2020-07-27 Online:2021-04-05 Published:2021-04-05
Contact: ^*liuqj246@163.com

摘要/Abstract

摘要： SUMO化修饰是蛋白质翻译后修饰的一种,在蛋白质的稳定性、蛋白质之间的相互作用和亚细胞定位等方面有重要的调节作用。蛋白质SUMO化修饰是糖尿病、肿瘤等疾病形成的主要机制,已成为治疗的关键靶点。本文就蛋白质SUMO化修饰与调控核因子 κB (NF-κB)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、转化生长因子-β(TGF-β)信号通路之间作用关系的最新进展做一综述。

关键词: SUMO化修饰, NF-κB, MAPK, TGF-β

Abstract: SUMO modification is a kind of post-translational modification of proteins, which plays an important role in regulating protein stability, protein-protein interaction and subcellular localization. SUMO modification of protein is the main mechanism for the formation of diabetes, tumors and other diseases.It has become the key target for treatment. In this article, we have reviewed the latest advance in the relationship between protein SUMO modification and these pathways which are nuclear factor-κB (NF-κB) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway and transforming growth factor-β (TGF-β).

Key words: SUMO modification, NF-κB, MAPK, TGF-β

中图分类号:

R365

肖云飞, 王嘉宾, 耿海刚, 刘青娟. SUMO化修饰及其对信号通路的调控[J]. 基础医学与临床, 2021, 41(4): 578-583.

XIAO Yun-fei, WANG Jia-bin, GENG Hai-gang, LIU Qing-juan. SUMO modification and its regulation of signaling pathways[J]. Basic & Clinical Medicine, 2021, 41(4): 578-583.

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