基础医学与临床 ›› 2017, Vol. 37 ›› Issue (11): 1640-1643.
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徐倩,哈小琴
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摘要: 自噬是机体重要的代谢过程,参与细胞的多种应激反应如炎性反应。自噬与炎性反应之间具有密切的分子联系。一方面,多种炎性反应介质可调控自噬发生及自噬基因的转录;另一方面,自噬通过多种方式可抑制机体过激的炎性反应。因此,机体的多种炎性反应疾病包括克罗恩病(CD)可能与自噬缺陷相关。
关键词: 自噬, 炎性反应, 克罗恩疾病
Abstract: Autophagy is a so important metabolism mechanism that involved in various stress responses of cells such as inflammation. A close molecular connection between autophagy and inflammation. One side, some inflammatory mediators can regulate autophagy and its translation; The other side, autophagy is able to suppress the excessive inflammation in various manners. Therefore, deficient autophagy may associate with inflammatory diseases such as Crohn’s Disease (CD).
Key words: Autophagy, inflammation, Crohn’s Disease
徐倩 哈小琴. 自噬与炎性反应之间分子联系的研究进展[J]. 基础医学与临床, 2017, 37(11): 1640-1643.
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