基础医学与临床 ›› 2015, Vol. 35 ›› Issue (2): 266-269.

• 短篇综述 • 上一篇    下一篇

Wnt信号通路与非小细胞肺癌的研究进展

左慧敏,曾林祥   

  1. 南昌大学第二附属医院
  • 收稿日期:2014-05-26 修回日期:2014-07-24 出版日期:2015-02-05 发布日期:2015-01-23
  • 通讯作者: 曾林祥 E-mail:zenglinxiang@sohu.com

Progress of Wnt signaling pathway and non-small cell lung cancer

  • Received:2014-05-26 Revised:2014-07-24 Online:2015-02-05 Published:2015-01-23

摘要: Wnt 信号通路在人类恶性肿瘤有着重要的调控作用。在非小细胞肺癌(NSCLC)细胞株,抑制Wnt通路能降低肿瘤扩散。Wnt信号因子影响非小细胞肺癌细胞的生长、分化、疾病的预后及化疗抗药性,可作为晚期非小细胞肺癌靶向治疗的新选择。

关键词: 非小细胞肺癌, wnt信号通路, 预后, 抗药性

Abstract: Wnt signaling pathway alterations are prominent in human malignancies.Wnt signaling is important in non-small cell lung cancer cell lines, and Wnt inhibition reduces proliferation. Wnt signaling substantially impacts NSCLC tumorigenesis, prognosis,and resistance to therapy. Wnt pathway as a therapeutic option in advanced NSCLC.

Key words: non-small cell lung cancer, wnt signaling Pathway, prognosis, drug resistance