基础医学与临床 ›› 2015, Vol. 35 ›› Issue (2): 257-261.
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李云1,宋银宏2,吕云波3
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摘要： MicroRNAs(MiRNAs)是一类高度保守的内源性非编码小分子单链RNA，它能通过非特异性识别靶基因mRNA，在翻译水平调节基因表达，从而调节细胞的多种生物功能。目前已发现多种miRNA，其中miR-126主要存在于血管内皮细胞及血小板中，与血管的生成、发育、修复功能密切相关，可以作为研究冠心病及其它血管性疾病的良好突破口。
关键词: miR-126, 血管, 血管内皮生长因子, 血管细胞粘附分子-1
Abstract: MicroRNAs (MiRNAs) is one kind of highly conservative endogenous non-coding single-stranded RNAs with small molecule, it is able to regulate gene expression at the translation level by non-specific identification of target genes’ mRNA, and it can regulate various biological functions of cells. Up to now a variety of microRNAs have been found, in which MiR-126 mainly exists in vascular endothelial cells and platelets, and is closely related to the generation, development and repairing of blood vessels. Therefore, MiR-126 will become a very good breach to study coronary heart disease and other vascular diseases.
Key words: miR-126, blood vessel, VEGF, VCAM-1
李云 宋银宏 吕云波. miR-126与血管的研究进展[J]. 基础医学与临床, 2015, 35(2): 257-261.
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