基础医学与临床 ›› 2015, Vol. 35 ›› Issue (1): 108-111.
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李熠,冯健,范忠才
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摘要： G蛋白偶联胆汁酸受体1(TGR5)是一种特殊的胆汁酸膜受体，在胆汁酸信号网中起着重要作用。它的激活可以控制血糖，调节血脂平衡，提高能量消耗，并发挥抗炎作用等，进而有望成为治疗一系列代谢性疾病的药物靶点。
关键词: TGR5, 糖代谢, 脂代谢, 能量代谢, 动脉粥样硬化
Abstract: G protein-coupled bile acid receptor 1(TGR5) is a specific membrane receptor of bile acids, playing an important role in the bile acid signaling network. Its activation has been proved to increase the glycemic control, regulate of blood lipid balance, enhance energy expenditure, exert anti-inflammatory actions and so on. It suggests that TGR5 may play an important role in metabolic diseases.
Key words: TGR5, glucose metabolism, lipid metabolism, energy metabolism, atherosclerosis
李熠 冯健 范忠才. TGR5是新型的代谢调节因子[J]. 基础医学与临床, 2015, 35(1): 108-111.
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