基础医学与临床 ›› 2011, Vol. 31 ›› Issue (3): 331-334.

• 短篇综述 • 上一篇    下一篇

Th17细胞相关细胞因子与皮肤疾病关系的研究进展

郑雯,马慧群   

  1. 西安交通大学医学院第二附属医院
  • 收稿日期:2010-03-05 修回日期:2010-05-12 出版日期:2011-03-05 发布日期:2011-03-14
  • 通讯作者: 马慧群 E-mail:mahuiqun2003@163.com

The Researching Progress of Th17 Cells Related Cytokines and Dermatosis

ZHENG Wen ,MA Hui-qun   

  1. The Second Affiliated Hospital of Xi'an Jiaotong University Medical College
  • Received:2010-03-05 Revised:2010-05-12 Online:2011-03-05 Published:2011-03-14
  • Contact: MA Hui-qun E-mail:mahuiqun2003@163.com

摘要: Th17细胞是不同于Th1,Th2细胞的辅助性T细胞,由Th17细胞分泌的细胞因子白细胞介素(IL)-17A、IL-17F、IL-21、IL-22、IL-6及肿瘤坏死因子α(TNF-α)等在皮肤疾病的发生、发展中起到重要的作用。对Th17细胞相关细胞因子与皮肤疾病关系的研究可进一步阐明银屑病、特应性皮炎等皮肤疾病发病机制,并为其治疗提供新的靶点。

关键词: Th17细胞, 细胞因子, 皮肤疾病

Abstract: Th17 cells are a newly appreciated T-helper cell subset, which distinct from both Th1 and Th2 cells. The cytokines produced by Th17 cells include IL-17A,IL-17F,IL-21,IL-22,IL-6,TNF-α and so on. These cytokines can play an important role in the onset and development of dermatosis. Investigations about the relationship between Th17 cells related cytokines and dermatosis may illustrated more about the nosogenesis of dermatosis such as psoriasis and atopic dermatitis,and provide new target for their therapy.

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