MBD2通路在重症哮喘中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.08.1165

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (8): 1165-1169.doi: 10.16352/j.issn.1001-6325.2024.08.1165

MBD2通路在重症哮喘中作用的研究进展

吴定将, 张秀峰^*

海南医学院第二附属医院呼吸内科,海南海口 570216

收稿日期:2023-12-28 修回日期:2024-04-01 出版日期:2024-08-05 发布日期:2024-07-24
通讯作者: ^*zxf96178@126.com
基金资助:
国家自然科学基金(81960006)

Progress on the role of MBD2 pathway in severe asthma

WU Dingjiang, ZHANG Xiufeng^*

Department of Respiratory Medicine, the Second Affiliated Hospital of Hainan Medical University, Haikou 570216, China

Received:2023-12-28 Revised:2024-04-01 Online:2024-08-05 Published:2024-07-24
Contact: ^*zxf96178@126.com

摘要/Abstract

摘要： 重症哮喘是一种对糖皮质激素治疗不敏感的慢性炎性疾病。在重症哮喘的发病过程中,辅助性T细胞17 (Th17) 及白细胞介素17 (IL-17) 起着重要的作用,主要是通过以聚集中性粒细胞浸润来加重哮喘的严重程度。甲基-CpG结合域蛋白2 (MBD2) 在Th17细胞由初始CD4⁺T细胞分化而来的过程中起着重要作用,能正向调控Th17分化和IL-17表达。MBD2与干扰素调节因子4(IRF4)、细胞因子信号转导抑制蛋白3 (SOCS3)、低氧诱导因子-1α(HIF-1α)及畸胎样激酶1(MINK1)启动子区的CpG岛结合,进而可导致甲基化,调节Th17细胞分化,并参与严重哮喘的发病机制。

关键词: 重症哮喘, 甲基-CpG结合域蛋白2(MBD2), 辅助性T细胞17

Abstract: Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment. In the pathogenesis of severe asthma, T helper cell 17(Th17) and interleukin 17 (IL-17) play an important role, mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma. Methyl-CpG-binding protein 2 (MBD2) plays an important role in the differentiation of Th17 cells from naive CD4⁺T cells,positively regulate Th17 differentiation and IL-17 expression. MBD2 binds to the CpG islands in the promoter region of interferon regulatory factor 4 (IRF4), suppressor of cytokine signaling 3 (SOCS3), hypoxia-inducible factor-1α (HIF-1α) and misshapen like kinase 1(MINK1), which leads to methylation, regulates the differentiation of Th17 cells, and participates in the pathogenesis of severe asthma.

Key words: severe asthma, methyl-CpG binding domain protein 2(MBD2), T helper 17 cells

中图分类号:

R562

吴定将, 张秀峰. MBD2通路在重症哮喘中作用的研究进展[J]. 基础医学与临床, 2024, 44(8): 1165-1169.

WU Dingjiang, ZHANG Xiufeng. Progress on the role of MBD2 pathway in severe asthma[J]. Basic & Clinical Medicine, 2024, 44(8): 1165-1169.

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MBD2通路在重症哮喘中作用的研究进展

Progress on the role of MBD2 pathway in severe asthma

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