西藏不同海拔地区藏族人群同型半胱氨酸水平

doi:10.16352/j.issn.1001-6325.2023.12.1841

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (12): 1841-1846.doi: 10.16352/j.issn.1001-6325.2023.12.1841

西藏不同海拔地区藏族人群同型半胱氨酸水平

李鹏昌¹, 邹雨桐¹, 刘治娟², 刘小星³, 泽吉普赤⁴, 田丽萍⁵, 吴洁^1*, 邱玲^1*

1.中国医学科学院北京协和医学院北京协和医院检验科疑难重症及罕见病国家重点实验室, 北京 100730;
2.西藏自治区人民医院检验科, 西藏拉萨 850000;
3.西藏阿里地区人民医院检验科, 西藏阿里 859000;
4.西藏日喀则市桑珠孜区人民医院检验科, 西藏日喀则 847000;
5.西藏林芝地区妇幼医院检验科, 西藏林芝 860000

收稿日期:2023-04-03 修回日期:2023-09-26 出版日期:2023-12-05 发布日期:2023-11-29
通讯作者: ^* qiul@pumch.cn; wujie@pumch.cn
基金资助:
西藏自治区科技计划(2016XZ01G20);西藏自治区自然科学基金(2015ZR-14-51)

Homocysteine level of Tibetan population settled down at different altitudes

LI Pengchang¹, ZOU Yutong¹, LIU Zhijuan², LIU Xiaoxing³, Zejipuchi⁴, TIAN Liping⁵, WU Jie^1*, QIU Ling^1*

1. Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730;
2. Department of Clinical Laboratory, Tibet Autonomous Region People's Hospital, Lhasa 850000;
3. Department of Clinical Laboratory, Ngari Prefecture People's Hospital, Ngari 859000;
4. Department of Clinical Laboratory, Shigatse City Sangzhuzi District People's Hospital, Shigatse 847000;
5. Department of Clinical Laboratory, Maternal and Child Health Hospital, Nyingchi 860000,China

Received:2023-04-03 Revised:2023-09-26 Online:2023-12-05 Published:2023-11-29
Contact: ^* qiul@pumch.cn; wujie@pumch.cn

摘要/Abstract

摘要： 目的调查分析西藏不同海拔地区藏族人群的同型半胱氨酸(Hcy)水平,探讨不同海拔地区、性别和年龄人群Hcy水平的差异,分析高同型半胱氨酸血症(HHcy)患病率及HHcy和非HHcy人群相关检验指标的差异。方法采用整群抽样法的原则,随机抽取西藏阿里地区、拉萨及日喀则市、林芝市3组高原地区1 615名受试者,经剔除后最终纳入1 428名(男性n=585)。采用Kruskal Wallis检验比较不同海拔地区、性别和年龄组间Hcy水平、使用Pearson卡方检验HHcy患病率的差异。采用方差分析不同检验指标在非HHcy与HHcy人群中的差异。结果不同海拔地区、不同性别间Hcy水平存在显著差异,男性高于女性,拉萨及日喀则地区高于林芝和阿里地区;在不同性别、地区、年龄组之间血清HHcy患病率均有差异,男性高于女性、拉萨及日喀则地区＞林芝地区＞阿里地区。受试者人群中总胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白B(ApoB)、肌酐(Cr)、尿素氮(Urea)、胱抑素C(CysC)、凝血Ⅴ因子(FⅤ)、蛋白C(PC)、免疫球蛋白A(IgA)、乳酸脱氢酶(LD)指标HHcy组显著高于非HHcy组,血清叶酸(SFA)、维生素B₁₂(VB₁₂)指标HHcy组显著低于非HHcy组。结论西藏高海拔地区人群HHcy发病率在不同地区、不同性别和不同年龄组间具有显著差异。通过分析Hcy水平和相关检验指标差异,为临床合理使用该指标,进一步为高原地区疾病的防治提供科学依据。

关键词: 同型半胱氨酸, 藏族人群, 高原地区, 高同型半胱氨酸血症, 患病率

Abstract: Objective To investigate and analyze the level of homocysteine (Hcy) in Tibet and to analyze the differences of Hcy level in different altitude regions, genders and ages, and thus to provide the prevalence profile of hyperhomocysteine and the differences in relevant tests between HHcy(hyperhomocysteinemia) and non-HHcy populations. Methods Totally 1 615(male n=585) subjects were selected from Ngari, Lhasa, Shigatse and Nyingchi plateau areas of Tibet by stratified cluster sampling. Serum Hcy level was analyzed and the difference of Hcy level in populations located at different altitude plateau areas, gender groups were found. The prevalence of hyperhomocysteine and related test were analyzed. Kruskal Wallis test was used to compare Hcy levels in different altitudes, genders and age groups, and Pearson Chi-square test was used to compare HHcy prevalence. Variance analysis was used for the differences of different test indicators between non-HHcy and HHcy populations. Results The level of Hcy in different regions and different genders were statistically significant, which was higher in males than that in females, and higher in Lhasa and Shigatse than in Nyingchi and Ngari. There was difference in serum HHcy prevalence among different genders, regions and age groups. Males showed a higher level than females, people from Lhasa and Shigatse showed a higher level than those from Nyingchi and Ngari. Conclusions The incidence of hyperhomocysteinemia in Tibet is statistically significant in different areas, different genders and different age groups. So this study provides a scientific basis for the rational use of Hcy as an indicator in clinical practice of prevention and treatment of related diseases in plateau areas.

Key words: homocysteine, Tibetan population, plateau, hyperhomocysteinemia, prevalence

中图分类号:

R446

李鹏昌, 邹雨桐, 刘治娟, 刘小星, 泽吉普赤, 田丽萍, 吴洁, 邱玲. 西藏不同海拔地区藏族人群同型半胱氨酸水平[J]. 基础医学与临床, 2023, 43(12): 1841-1846.

LI Pengchang, ZOU Yutong, LIU Zhijuan, LIU Xiaoxing, Zejipuchi, TIAN Liping, WU Jie, QIU Ling. Homocysteine level of Tibetan population settled down at different altitudes[J]. Basic & Clinical Medicine, 2023, 43(12): 1841-1846.

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西藏不同海拔地区藏族人群同型半胱氨酸水平

Homocysteine level of Tibetan population settled down at different altitudes

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