烟曲霉IgG对变应性支气管肺曲霉菌病复发的监测意义

doi:10.16352/j.issn.1001-6325.2023.08.1280

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (8): 1280-1283.doi: 10.16352/j.issn.1001-6325.2023.08.1280

烟曲霉IgG对变应性支气管肺曲霉菌病复发的监测意义

汤蕊^1#, 雷曙槟^2#, 孙劲旅^1*

1.中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科过敏性疾病精准诊疗研究北京市重点实验室国家免疫性疾病临床医学研究中心(NCRC-DID),北京 100730;
2.中国医学科学院北京协和医学院八年制临床医学专业,北京 100730

收稿日期:2022-05-07 修回日期:2022-09-29 出版日期:2023-08-05 发布日期:2023-07-26
通讯作者: ^*18611382050@163.com
作者简介:^#对本文有相同贡献
基金资助:
中国医学科学院医学与健康科技创新工程项目(2020-I2M-C&T-B-001)

Monitoring effect of Aspergillus fumigatus specific IgG for recurrence of allergic bronchopulmonary aspergillosis

TANG Rui^1#, LEI Shubin^2#, SUN Jinlyu^1*

1. Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID),Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730;
2. Eight-year Medical Doctor Program, CAMS & PUMC, Beijing 100730, China

Received:2022-05-07 Revised:2022-09-29 Online:2023-08-05 Published:2023-07-26
Contact: ^*18611382050@163.com

摘要/Abstract

摘要： 目的探究变应性支气管肺曲霉菌病(ABPA)复发的血清学监测指标。方法收集2001年6月至2021年9月在北京协和医院变态反应科门诊以变应性支气管肺曲霉菌病随访的18例患者的临床资料,进行统计学分析。结果对18例患者共68次有效随访信息进行分析,共建立3个广义线性估计模型,包括变量分别为:1)模型1,血清烟曲霉特异性IgG(Gm3)水平;2)模型2,血清Gm3水平及患者性别、年龄;3)模型3,血清Gm3水平、血清烟曲霉特异性IgE水平及外周血白细胞水平。血清Gm3在上述3个模型中均为ABPA症状复发的独立危险因素。结论血清Gm3水平对ABPA复发有一定预测意义,是潜在的临床血清学监测指标。

关键词: 变应性支气管肺曲霉菌病, 烟曲霉特异性IgG, 监测指标, 复发

Abstract: Objective To investigate serological monitoring indicator of the recurrence of allergic broncho-pulmonary aspergillosis (ABPA). Methods The follow-up records of 18 outpatients in Peking Union Medical College Hospital from June 2001 to September 2021 were collected and analyzed statistically. Results In total, 68 records of 18 patients had been analyzed. Three models were conducted, model 1 included serological Aspergillus fumigatus specific IgG(Gm3) level as a single variant, model 2 added gender and age based on model 1, and model 3 added Aspergillus fumigatus specific IgE level and the count of white blood cells based on model 1. Serological Gm3 level was an independent risk factor in all 3 models. Conclusions Serological Gm3 level is potential serological marker used in monitoring the recurrence of ABPA.

Key words: allergic bronchopulmonary aspergillosis, Aspergillus fumigatus specific IgG, monitoring factor, recurrence

中图分类号:

R563.9

汤蕊, 雷曙槟, 孙劲旅. 烟曲霉IgG对变应性支气管肺曲霉菌病复发的监测意义[J]. 基础医学与临床, 2023, 43(8): 1280-1283.

TANG Rui, LEI Shubin, SUN Jinlyu. Monitoring effect of Aspergillus fumigatus specific IgG for recurrence of allergic bronchopulmonary aspergillosis[J]. Basic & Clinical Medicine, 2023, 43(8): 1280-1283.

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烟曲霉IgG对变应性支气管肺曲霉菌病复发的监测意义

Monitoring effect of Aspergillus fumigatus specific IgG for recurrence of allergic bronchopulmonary aspergillosis

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