The modification and application precautions of the WHO classification of tumors of the central nervous system (fifth edition)

doi:10.3969/j.issn.1672-6731.2026.01.001

Abstract

Abstract:

The fifth edition of the WHO classification of tumors of the central nervous system (CNS5, 2021) is based on the concept of precision medicine. CNS5 incorporates a large number of new molecular diagnostic indicators as well as more detailed clinical and molecular epidemiological follow-up data. Through this, CNS5 has formulated new schemes for reclassifying, sub-classifying, typing, sub-typing, grading, and/or renaming of CNS tumors, and also added a large number of new tumor entities, significantly improving the accuracy, reproducibility, and consistency of diagnosis. This article briefly describes the main modification and significance of CNS5 and the precautions for its application.

Key words: Central nervous system neoplasms, World Health Organization, The fifth edition (not in MeSH)

摘要：

WHO中枢神经系统肿瘤分类第5版（CNS5，2021年）基于精准医学理念，引入大量新的分子诊断指标及更详细的临床和分子流行病学随访数据，籍此制定对中枢神经系统肿瘤重新分类、亚分类、分型、亚分型、分级和（或）重新命名的新方案，增加大量新的肿瘤实体，显著提升诊断的精确性、可重复性和一致性。本文简述CNS5的主要变更和意义及其应用注意事项。

关键词: 中枢神经系统肿瘤, 世界卫生组织, 第5版(非MeSH词)

CLC Number:

R739.4
R602

Shi-zhu YU, Cui-yun SUN. The modification and application precautions of the WHO classification of tumors of the central nervous system (fifth edition)[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2026, 26(1): 1-7.

于士柱, 孙翠云. WHO中枢神经系统肿瘤分类第5版变更及应用注意事项[J]. 中国现代神经疾病杂志, 2026, 26(1): 1-7.

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References 15

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