Current research status and developmental direction of animal models of cerebral venous sinus thrombosis

doi:10.3969/j.issn.1672-6731.2020.03.017

Abstract

Abstract:

The pathogenesis and pathophysiological process of cerebral venous sinus thrombosis (CVST) are different from that of ischemic stroke. The establishment of an appropriate animal model of CVST is helpful to the further research of pathogenesis, pathophysiological process and the choice of treatment strategy. However, at present, most animal models are only short-term observations, which are not suitable for long-term studies and can not well simulate the pathogenesis and pathophysiology of human CVST. This article reviews the preparation, advantages and disadvantages of various animal models of CVST, and the current research status, in order to lay a theoretical foundation and clear development direction for the study of a new method of preparing animal models of CVST with high success rate and high fitting degree.

Key words: Sinus thrombosis,intracranial, Disease models,animal, Review

摘要：

颅内静脉窦血栓形成的病理生理学过程与缺血性卒中有所不同，制备合适的动物模型有助于深入研究其发病机制、病理生理学过程和选择治疗策略。然而，目前大部分动物模型仅能完成短期观察，不适用于长期研究且不能较好地模拟人类颅内静脉窦血栓形成的发病过程。本文拟通过对不同类型颅内静脉窦血栓形成动物模型制备方法及优缺点、研究现状进行综述，以为研究一种成功率和拟合度较高的新型颅内静脉窦血栓形成动物模型的制备方法奠定理论基础，并明确研究方向。

关键词: 窦血栓形成,颅内, 疾病模型,动物, 综述

XIAO Li-po, ZHAO Ting-yu, DUAN Jian-gang, JI Xun-ming. Current research status and developmental direction of animal models of cerebral venous sinus thrombosis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(3): 242-247.

肖立坡, 赵婷玉, 段建钢, 吉训明. 颅内静脉窦血栓形成动物模型研究现状及发展方向[J]. 中国现代神经疾病杂志, 2020, 20(3): 242-247.

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