Abstract:

Cognitive dysfunction is common non-motor symptom (NMS) in Parkinson's disease (PD), which affects the patients' quality of life and increases the burden of caregivers. Cognitive dysfunction in PD can be mild cognitive impairment (MCI) or dementia. MCI presents in the early stage of PD and the incidence rate is increasing with the disease progression. In some cases it can advance to dementia. The diagnosis of MCI in PD includes inclusion criteria, exclusion criteria and damage level evaluation. Non-pharmacological therapy, such as exercise and cognitive behavior therapy (CBT) can improve the symptoms of MCI in PD, while the pharmacological treatment remains to be further studied.

Key words: Parkinson disease, Cognition disorders, Review

摘要：

认知功能障碍是帕金森病较为常见的非运动症状，影响帕金森病患者生活质量、增加照料者负担。帕金森病认知功能障碍可以表现为轻度认知损害，也可以表现为痴呆。帕金森病轻度认知损害见于疾病早期，随着病情进展发病率逐渐升高，可进展为帕金森病痴呆。帕金森病轻度认知损害的诊断标准包括纳入标准、排除标准和损害水平判断。非药物治疗如运动锻炼和认知行为疗法可以改善帕金森病轻度认知损害症状，其药物治疗尚待进一步研究。

关键词: 帕金森病, 认知障碍, 综述