Abstract:

Objective  To study the risk factors for vascular cognitive impairment (VCI) after lacunar infarct (LACI).  Methods  A total of 138 patients with LACI were evaluated by Montreal Cognitive Assessment (MoCA), and divided into normal cognitive function group (normal, N = 55), mild cognitive impairment (MCI) group (mild, N = 73) and severe cognitive impairment group (severe, N = 10). Univariate and backward multivariate Logistic regression analysis were used to screen the risk factors for VCI after LACI.  Results  Logistic regression analysis showed that infarct in critical site (OR = 1.179, 95% CI: 0.870-2.472; P = 0.012) and white matter hyperintensity (WMH) Grade 3-4 (OR = 2.005, 95% CI: 0.910-4.502; P = 0.024) were independent risk factors for VCI in patients with LACI.  Conclusions  VCI in patients with LACI is related to multiple factors, in which infarct in critical site and WMH Grade 3-4 are independent risk factors.

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摘要：

目的 探讨腔隙性梗死后血管性认知损害的相关危险因素。方法 共138 例腔隙性梗死患者根据蒙特利尔认知评价量表分为认知功能正常55例、轻度认知功能障碍73例和重度认知功能障碍10 例，采用单因素和多因素后退法Logistic 回归分析筛查腔隙性梗死后血管性认知损害相关危险因素。结果 关键部位梗死灶（OR = 1.179，95%CI：0.870 ~ 2.472；P = 0.012）和脑白质高信号3 ~ 4 级（OR =2.005，95%CI：0.910 ~ 4.502；P = 0.024）是腔隙性梗死患者出现血管性认知损害的独立危险因素。结论 腔隙性梗死后血管性认知损害是多因素共同作用的结果，其中关键部位梗死灶和脑白质高信号3 ~4级是独立危险因素。

关键词: 脑梗死, 认知障碍, 危险因素, 回归分析