Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2015, Vol. 15 ›› Issue (7): 531-538. doi: 10.3969/j.issn.1672-6731.2015.07.006

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Research progress of behavioral variant frontotemporal dementia

GU Xiao-hua1, XU Jun2   

  1. 1Intensive Care Unit, 2Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China
  • Online:2015-07-25 Published:2015-07-22
  • Contact: XU Jun (Email: 13611572068@126.com)
  • Supported by:

    This study was supported by "Major New Drugs Innovation and Development" Project of Ministry of Science and Technology (No. 2012ZX09303-003, 2012ZX09303005-002), National Natural Science Foundation of China (No. 81471215, 81271211, 30700248), Science and Technology Support Project of Jiangsu Province (No. BE2011614), Open Project of Key Laboratory of Jiangsu Province (No. SJ11KF05), Jiangsu Province "333 High-Level Talents" Third Level [No. (2013) Ⅲ-0077], "Six Peaks of Talents" Support Program of Jiangsu Province (No. 2012-WS-002) and "Lü Yang Jin Feng" Innovation Leading Personnel (No. yzlyjfjh2013CX056).

行为异常型额颞叶痴呆研究进展

顾小花, 徐俊   

  1. 225001 扬州，江苏省苏北人民医院重症医学科（顾小花），神经内科（徐俊）
  • 通讯作者: 徐俊（Email：13611572068@126.com）
  • 基金资助:

    科技部“ 重大新药创制”重大专项项目（项目编号：2012ZX09303-003）；科技部“ 重大新药创制”重大专项项目（项目编号：2012ZX09303005-002）；国家自然科学基金资助项目（项目编号：81471215）；国家自然科学基金资助项目（项目编号：81271211）；国家自然科学基金资助项目（项目编号：30700248）；江苏省科技支撑计划项目（项目编号：BE2011614）；江苏省重点实验室开放课题（项目编号：SJ11KF05）；江苏省“333 高层次人才培养工程”资助项目［项目编号：（2013）Ⅲ-0077 号］；江苏省“六大人才高峰”资助项目（项目编号：2012-WS-002）；江苏省扬州市“绿扬金凤计划”创新领军人才项目（项目编号：yzlyjfjh2013CX056）

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Abstract:

There is no epidemiological data of frontotemporal dementia (FTD) in China. The application of updated diagnostic criteria, publishing of frontotemporal lobar degeneration (FTLD) consensus in China, development of multimodal imaging and biomarkers promote the clinical understanding on behavioral variant frontotemporal dementia (bvFTD). There is still no drugs treating FTD approved by U.S. Food and Drug Administration (FDA). Multidisciplinary intervention may delay the progression of bvFTD.

Key words: Dementia, Frontal lobe, Temporal lobe, Biological markers, Review

摘要：

鉴于我国目前尚无额颞叶痴呆的流行病学资料，行为异常型额颞叶痴呆国际标准联盟公布的新的诊断标准与我国专家共识、多模态影像学和生物学标志物研究有望提高临床对行为异常型额颞叶痴呆的认识，多种干预措施可能延缓病情进展。

关键词: 痴呆, 额叶, 颞叶, 生物学标记, 综述

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