Abstract: The curative effect of cinepazide maleate (320 mg/d) and nimodipine (30 mg/d) on the cerebral vasospasm caused by post-traumatic subarachnoid hemorrhage was compared. Transcranial Doppler ultrasound (TCD) was used to examine the changes of hemodynamics of middle cerebral artery (MCA) before and after treatment. On the 3rd day after treatment the blood flow velocity of MCA in both groups decreased obviously, and the difference between that in pre- and post-treatment was statistically significant (cinepazide maleate group t = 4.364, P = 0.000; nimodipine group t = 7.486, P = 0.000), but there was no statistically significant difference between 2 groups (P = 0.124). On the 7th day, the blood flow velocity of 2 groups continously declined (cinepazide maleate group t = 5.793, P = 0.000; nimodipine group t = 10.364, P = 0.000), but there was no significant difference between 2 groups (P = 0.364). No statistically significant difference on total effective rate and adverse drug reaction rate was seen between 2 groups (P > 0.05). It was suggested that cinepazide maleate can replace nimodipine in the treatment for cerebral vasospasm after subarachnoid hemorrhage.

Key words: Maleates, Nimodipine, Subarachnoid hemorrhage, traumatic, Vasospasm, intracranial

摘要： 通过经颅多普勒超声观察马来酸桂哌齐特（320 mg/d）和尼莫地平（30 mg/d）治疗前后创伤性蛛网膜下隙出血所致脑血管痉挛患者大脑中动脉血流动力学变化。结果显示，与治疗前相比，两组患者治疗第3和7天时大脑中动脉血流速度［第3天：（131.03 ± 15.03）cm/s对（135.93 ± 12.94）cm/s；第7天：（118.90 ± 13.84）cm/s 对（121.78 ± 14.19）cm/s］下降（均P = 0.000），但组间差异无统计学意义（均P >0.05）。两组患者治疗总有效率和药物不良反应发生率比较，差异均无统计学意义（P > 0.05）。提示马来酸桂哌齐特可以替代尼莫地平治疗蛛网膜下隙出血后脑血管痉挛。

关键词: 马来酸盐类, 尼莫地平, 蛛网膜下腔出血, 创伤性, 脑血管痉挛, 颅内