Abstract:

Severe cerebral venous thrombosis (CVT) is associated with serious clinical manifestations and poor prognosis, and current therapeutic strategies fail to substantially improve outcomes, necessitating exploration of novel therapeutic approaches. The latest studies have shown that inflammation is closely associated with the severity and poor prognosis of severe CVT, and anti?inflammatory therapy may be a very promising treatment. Despite ongoing debate regarding the role of glucocorticoids in severe CVT, recent studies indicate that short? term glucocorticoids pulse therapy may be a safe and effective intervention in acute/subacute severe CVT, which are likely due to suppression of the inflammatory response. This paper focuses on the latest research progress of glucocorticoids therapy for severe CVT, and points out that anti?inflammatory therapy targeting inflammation has great research potential in improving the prognosis of severe CVT. We wish to provide a novel, accessible, effective and safe anti? inflammatory therapy for patients with severe CVT.

Key words: Venous thrombosis, Cerebral veins, Critical illness, Glucocorticoids, Inflammation

摘要：

重症脑静脉血栓形成患者临床症状严重，预后较差，现有治疗方案无法明显改善预后，亟待探索新的治疗手段。炎症反应与重症脑静脉血栓形成严重程度和不良预后相关，抗炎症治疗可能是颇具前景的治疗手段。糖皮质激素用于重症脑静脉血栓形成的治疗一直存有争议，新近研究提示，糖皮质激素短期冲击治疗联合抗凝治疗可能是急性或亚急性重症脑静脉血栓形成安全、有效的治疗措施，其疗效可能与抑制炎症反应有关。因此，梳理糖皮质激素治疗重症脑静脉血栓形成的研究成果、分析以炎症为靶点的抗炎症治疗对改善患者预后的临床潜力，可以为重症脑静脉血栓形成的治疗提供一种新的、可行的、有效且安全的抗炎症治疗方案。

关键词: 静脉血栓形成, 脑静脉, 危重病, 糖皮质激素类, 炎症