Progress on excessive daytime sleepiness secondary to ischemic stroke

doi:10.3969/j.issn.1672-6731.2023.08.006

Abstract

Abstract:

Excessive daytime sleepiness (EDS) is a common complication of ischemic stroke, which can lead to lack of rehabilitation motivation, further decline of cognitive function, reduced quality of life, and significantly increased risk of poor prognosis. This article reviews the epidemiological characteristics, subtypes, pathogenesis and treatment progress of EDS secondary to ischemic stroke, in order to improve the diagnosis and treatment of the disease.

Key words: Ischemic stroke, Disorders of excessive somnolence, Review

摘要：

日间过度思睡是缺血性卒中的常见并发症，可导致患者康复动力缺乏、认知功能减退、生活质量下降，使预后不良风险显著增加。本文对缺血性卒中继发日间过度思睡的流行病学特点、继发日间过度思睡的缺血性卒中亚型、发病机制及治疗进展进行综述，以提高疾病诊断与治疗水平。

关键词: 缺血性卒中, 过度嗜睡性障碍, 综述

Cheng-xin KU, Li-ying DENG, Liang XIE. Progress on excessive daytime sleepiness secondary to ischemic stroke[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(8): 683-686.

库成心, 邓丽影, 谢亮. 缺血性卒中继发日间过度思睡研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 683-686.

/ / Recommend / Download Citations

URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2023.08.006

https://journal11.magtechjournal.com/cjcnn/EN/Y2023/V23/I8/683

References 36

1	Zhao Y , Zhang X , Chen X , Wei Y . Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review. Int J Mol Med, 2022, 49: 15.
2	Wang WY , Chen G . Advances in the study of factors and treatment of secondary daytime somnolence after stroke and its influence on prognosis. Zhongguo Quan Ke Yi Xue, 2021, 24: 1570- 1574. doi: 10.12114/j.issn.1007-9572.2021.00.057
	王文熠, 陈光. 脑卒中后继发昼间嗜睡的影响因素与治疗及其对预后的影响研究进展. 中国全科医学, 2021, 24: 1570- 1574. doi: 10.12114/j.issn.1007-9572.2021.00.057
3	Cai H , Wang XP , Yang GY . Sleep disorders in stroke: an update on management. Aging Dis, 2021, 12: 570- 585. doi: 10.14336/AD.2020.0707
4	Al-Dughmi M , Al-Sharman A , Stevens S , Siengsukon CF . Sleep characteristics of individuals with chronic stroke: a pilot study. Nat Sci Sleep, 2015, 7: 139- 145.
5	Ding Q , Whittemore R , Redeker N . Excessive daytime sleepiness in stroke survivors: an integrative review. Biol Res Nurs, 2016, 18: 420- 431. doi: 10.1177/1099800415625285
6	Šiarnik P , Klobučníková K , Šurda P , Putala M , Šutovský S , Kollár B , Turčáni P . Excessive daytime sleepiness in acute ischemic stroke: association with restless legs syndrome, diabetes mellitus, obesity, and sleep-disordered breathing. J Clin Sleep Med, 2018, 14: 95- 100. doi: 10.5664/jcsm.6890
7	Duss SB , Bauer-Gambelli SA , Bernasconi C , Dekkers MPJ , Gorban-Peric C , Kuen D , Seiler A , Oberholzer M , Alexiev F , Lippert J , Brill AK , Ott SR , Zubler F , Horvath T , Schmidt MH , Manconi M , Bassetti CLA . Frequency and evolution of sleep-wake disturbances after ischemic stroke: a 2-year prospective study of 437 patients. Sleep Med, 2023, 101: 244- 251. doi: 10.1016/j.sleep.2022.10.007
8	Kojic B , Dostovic Z , Vidovic M , Ibrahimagic OC , Hodzic R , Iljazovic A . Sleep disorders in acute stroke. Mater Sociomed, 2022, 34: 14- 24. doi: 10.5455/msm.2022.33.14-18
9	Pradeep R , Gupta D , Mehta A , Srinivasa R , Javali M , Acharya PT . Wake-up sleepyhead: unilateral diencephalic stroke presenting with excessive sleepiness. J Neurosci Rural Pract, 2019, 10: 145- 147. doi: 10.4103/jnrp.jnrp_258_18
10	Hansen PN , Krøigård T , Nguyen N , Frandsen RV , Jennum PJ , Beier CP . Severe hypersomnia after unilateral infarction in the pulvinar nucleus: a case report. BMC Neurol, 2020, 20: 442. doi: 10.1186/s12883-020-02018-2
11	Saida IB , Saad HB , Zghidi M , Ennouri E , Ettoumi R , Boussarsar M . Artery of Percheron stroke as an unusual cause of hypersomnia: a case series and a short literature review. Am J Mens Health, 2020, 14: 1557988320938946.
12	Kong W , Ma L , Yin C , Zhao W , Wang Y . Unilateral thalamic infarction onset with lethargy: a case report and literature review. Medicine (Baltimore), 2022, 101: e32158. doi: 10.1097/MD.0000000000032158
13	Matsubara T , Suzuki K , Kawasaki A , Miyamoto M , Okamura M , Kanbayashi T , Takekawa H , Nakamura T , Watanabe Y , Matsubara M , Hirata K . Sudden onset of sleep caused by hypothalamic infarction: a case report. BMC Neurol, 2019, 19: 182. doi: 10.1186/s12883-019-1414-3
14	Wang Z , Zhong YH , Jiang S , Qu WM , Huang ZL , Chen CR . Case report: dysfunction of the paraventricular hypothalamic nucleus area induces hypersomnia in patients. Front Neurosci, 2022, 16: 830474. doi: 10.3389/fnins.2022.830474
15	Ren S , Wang Y , Yue F , Cheng X , Dang R , Qiao Q , Sun X , Li X , Jiang Q , Yao J , Qin H , Wang G , Liao X , Gao D , Xia J , Zhang J , Hu B , Yan J , Wang Y , Xu M , Han Y , Tang X , Chen X , He C , Hu Z . The paraventricular thalamus is a critical thalamic area for wakefulness. Science, 2018, 362: 429- 434. doi: 10.1126/science.aat2512
16	Eban-Rothschild A , Rothschild G , Giardino WJ , Jones JR , de Lecea L . VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors. Nat Neurosci, 2016, 19: 1356- 1366. doi: 10.1038/nn.4377
17	Shan L , Balesar R , Swaab DF , Lammers GJ , Fronczek R . Reduced numbers of corticotropin-releasing hormone neurons in narcolepsy type 1. Ann Neurol, 2022, 91: 282- 288. doi: 10.1002/ana.26300
18	Xu M , Chung S , Zhang S , Zhong P , Ma C , Chang WC , Weissbourd B , Sakai N , Luo L , Nishino S , Dan Y . Basal forebrain circuit for sleep-wake control. Nat Neurosci, 2015, 18: 1641- 1677. doi: 10.1038/nn.4143
19	Wang Z , Zhong YH , Jiang S , Qu WM , Huang ZL , Chen CR . Case report: dysfunction of the paraventricular hypothalamic nucleus area induces hypersomnia in patients. Front Neurosci, 2022, 16: 830474. doi: 10.3389/fnins.2022.830474
20	Fan AY , Zhang YL , Huang GQ , Wang QZ , He JQ . Analysis of related factors of excessive daytime sleepiness after acute stroke. Zhong Feng Yu Sheng Jing Ji Bing Za Zhi, 2019, 36: 517- 519. doi: 10.19845/j.cnki.zfysjjbzz.2019.06.009
	范爱月, 张焱磊, 黄桂乾, 王琼章, 何金彩. 急性脑卒中后日间过度嗜睡相关因素分析. 中风与神经疾病杂志, 2019, 36: 517- 519. doi: 10.19845/j.cnki.zfysjjbzz.2019.06.009
21	Zhang XF , Zhang MW , Yu ZH , Zhu L , Zhou YL . Application of diffusion tensor imaging in patients with coma after traumatic brain injury. Guo Ji Shen Jing Bing Xue Sheng Jing Wai Ke Xue Za Zhi, 2019, 46: 31- 34. URL
	张晓峰, 张明文, 于志虎, 朱林, 周雁玲. 弥散张量成像在颅脑损伤昏迷病人中的应用. 国际神经病学神经外科学杂志, 2019, 46: 31- 34. URL
22	Kwak S , Chang MC . Impaired consciousness due to injury of the ascending reticular activating system in a patient with bilateral pontine infarction: a case report. Transl Neurosci, 2020, 11: 264- 268. doi: 10.1515/tnsci-2020-0138
23	Sadiq W , Subhan M . Ischemic stroke of midbrain and cerebellum involving reticular activating system. Cureus, 2017, 9: e1637.
24	Fonseca AC , Geraldes R , Pires J , Falcão F , Bentes C , Melo TP . Improvement of sleep architecture in the follow up of a patient with bilateral paramedian thalamic stroke. Clin Neurol Neurosurg, 2011, 113: 911- 913. doi: 10.1016/j.clineuro.2011.05.003
25	Goyal MK , Kumar G , Sahota PK . Isolated hypersomnia due to bilateral thalamic infarcts. J Stroke Cerebrovasc Dis, 2012, 21: 146- 147. doi: 10.1016/j.jstrokecerebrovasdis.2010.05.013
26	Chen CR , Zhong YH , Jiang S , Xu W , Xiao L , Wang Z , Qu WM , Huang ZL . Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice. Elife, 2021, 10: e69909. doi: 10.7554/eLife.69909
27	Maski K , Trotti LM , Kotagal S , Robert Auger R , Rowley JA , Hashmi SD , Watson NF . Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med, 2021, 17: 1881- 1893. doi: 10.5664/jcsm.9328
28	Visser MM , Goodin P , Parsons MW , Lillicrap T , Spratt NJ , Levi CR , Bivard A . Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue. Sci Rep, 2019, 9: 9660. doi: 10.1038/s41598-019-46149-0
29	Cross DB , Tiu J , Medicherla C , Ishida K , Lord A , Czeisler B , Wu C , Golub D , Karoub A , Hernandez C , Yaghi S , Torres J . Modafinil in Recovery after Stroke (MIRAS): a retrospective study. J Stroke Cerebrovasc Dis, 2020, 29: 104645. doi: 10.1016/j.jstrokecerebrovasdis.2020.104645
30	Gao JY , Tang T , Sun HY , Xiong LL , Ye HM . Clinical features of sleep disorders in patients with acute cerebral infarction and their relationship to the site of the infarct. Inner Mongolia Yi Ke Da Xue Xue Bao, 2020, 42: 505- 508. URL
	高军毅, 唐涛, 孙海燕, 熊璐璐, 叶惠明. 急性脑梗死患者睡眠障碍的临床特点及其与脑梗部位的关系. 内蒙古医科大学学报, 2020, 42: 505- 508. URL
31	Takenoshita S , Nishino S . Pharmacologic management of excessive daytime sleepiness. Sleep Med Clin, 2020, 15: 177- 194. doi: 10.1016/j.jsmc.2020.02.006
32	Greenblatt K , Adams N . Modafinil. Treasure Island (FL): StatPearls Publishing, 2023.
33	Yuan YL , Zhu YL , Liu XH . Clinical observation of Xingnaojing injection for acute ischemic stroke. Liaoning Zhong Yi Za Zhi, 2023, 1- 5. URL
	袁艳丽, 朱艳丽, 刘兴华. 醒脑静注射液治疗急性缺血性脑卒中临床观察. 辽宁中医杂志, 2023, 1- 5. URL
34	Wang CX , Sun JC , Zhang J . Efficacy of Xingnaojing injection for acute cerebral infarction. Dang Dai Yi Yao Lun Cong, 2018, 16: 119- 120. URL
	王春秀, 孙景存, 张娟. 醒脑静注射液治疗急性脑梗死的效果观察. 当代医药论丛, 2018, 16: 119- 120. URL
35	Duan L , Ding SY . Clinical efficacy of bufetil sodium chloride injection in the treatment of early cerebral infarction. Zhongguo Shi Yong Yi Yao, 2023, 18: 6- 9. URL
	段丽, 丁姝月. 早期脑梗死应用丁苯酞氯化钠注射液治疗的临床效果探讨. 中国实用医药, 2023, 18: 6- 9. URL
36	Wei CB , Huang QL , Wei J . Combined Xingnaojing with Butylohthalide in patients with acute posterior circulation cerebral infarction. Shen Jing Sun Shang Yu Gong Neng Chong Jian, 2022, 17: 432- 433. URL
	魏从兵, 黄启亮, 魏进. 丁苯酞联合醒脑静改善急性后循环脑梗死患者日间过度嗜睡状态. 神经损伤与功能重建, 2022, 17: 432- 433. URL

[1]	Zhi-yong TONG. Intracranial aneurysms and cerebral revascularization [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 595-598.
[2]	Zhi-yong TONG. History of cerebral revascularization [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 599-605.
[3]	Ling-ji JIN, Jun-wen HU, Yin LI, Lin WANG. Intracranial-intracranial bypass for the treatment of complex intracranial aneurysms: technical advances and surgical experience [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 606-612.
[4]	Pei-xi LIU, Yuan SHI, Wei ZHU. Application of whole-region cerebral vascular bypass for intracranial aneurysms treatment in the flow diversion era [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 613-618.
[5]	Feng ZHANG, Fan-gang MENG. Research progress of subthalamic nucleus deep brain stimulation in treatment of autonomic nerve dysfunction in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 510-515.
[6]	Gui-zhi WU, Hong TIAN. Clinical research progress of deep brain stimulation for Meige's syndrome [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 516-521.
[7]	Fan-gang MENG, Jian-guo ZHANG. Application of retroauricular bone grinding groove technology in deep brain stimulation [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 522-524.
[8]	Lin CHEN, Hua PAN. Electrophysiological diagnosis of functional tremor [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 573-578.
[9]	Jun-ji WEI, Jian-bo CHANG. Promoting the concept of neurosurgical critical care in primary hospitals [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 403-406.
[10]	Ruo-lin SHI, Xiu-jie GAO, Jia-ning CUI, Yan SHAO, Lu-shuang XIE, Yi LIU. Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 497-501.
[11]	Hai-feng LI. Glucocorticoids remain the basis for treatment of myasthenia gravis in the era of targeted therapies [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 295-307.
[12]	Hong-jia XU, Ya-qing SHU, Pin WANG, Fan LI, Shun-liang XU, Wei QIU, Xiao-yu MA. Advances on the diagnosis and treatment of aquaporin 4 antibody positive neuromyelitis optica spectrum disorders [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 308-314.
[13]	Yu HUANG, Jin-chi LIAO, Ya-qing SHU. Progress on sleep disorders in anti-N-methyl-D-aspartate receptor encephalitis [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 315-319.
[14]	Cai-yun LIU, Tao JIN. Immunotherapeutic potential of dendritic cells in multiple sclerosis [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 320-330.
[15]	Mei-yan SHI, Xian-jun ZHANG, Xian-wei WANG, Yong ZHANG, Nai-dong WANG. Intracranial arterial stenosis stenting via radial artery approach: four cases report [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 382-390.

Please choose a citation manager

Content to export