Non-pharmacological interventions of early Alzheimer's disease should be emphasized

doi:10.3969/j.issn.1672-6731.2021.11.001

Abstract

Abstract:

Alzheimer's disease (AD) is a neurodegeneration disease, characterized by progressive decline of global cognition with memory impairment as its early and the most prominent manifestation. AD is the most common type of dementia. The prevalence of AD is increasing every year. The mechanisms of AD are complicated and there are limited effects of drug therapies. Non-pharmacological interventions including physical activity, cognitive training, life-style treatments, psychological and music therapies, etc. could delay the process of AD through multiple ways. Non-pharmacological interventions of early AD should be emphasized, and we should combine various pharmacological and non-pharmacological interventions together, which will maximum optimize the effects of treatments for clinical symptoms.

Key words: Alzheimer disease, Sports, Cognitive therapy, Healthy lifestyle, Psychotherapy, Review

摘要：

阿尔茨海默病是以记忆损害为早期表现和特征的缓慢进展的神经退行性疾病，为最常见的痴呆类型。发病率逐年升高，发病机制复杂，药物治疗效果欠佳，而运动锻炼、认知训练、生活方式干预、心理治疗和音乐疗法等非药物治疗可以通过多种途径减缓阿尔茨海默病的发生发展。因此，应重视早期阿尔茨海默病的非药物治疗，联合药物治疗和多种非药物治疗方法进行多靶点干预，以期最大化改善患者临床症状。

关键词: 阿尔茨海默病, 体育运动, 认知疗法, 健康生活方式, 心理疗法, 综述

CHEN Sheng-di, FANG Rong. Non-pharmacological interventions of early Alzheimer's disease should be emphasized[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(11): 913-917.

陈生弟, 方嵘. 应重视早期阿尔茨海默病的非药物治疗[J]. 中国现代神经疾病杂志, 2021, 21(11): 913-917.

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References

[1] Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, Li Y, Li Y, Zhu M, Jiao H, Song Y, Shi Y, Zhang H, Gong M, Wei C, Tang Y, Fang B, Guo D, Wang F, Zhou A, Chu C, Zuo X, Yu Y, Yuan Q, Wang W, Li F, Shi S, Yang H, Zhou C, Liao Z, Lv Y, Li Y, Kan M, Zhao H, Wang S, Yang S, Li H, Liu Z, Wang Q, Qin W, Jia J; COAST Group. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China:a cross-sectional study[J]. Lancet Public Health, 2020, 5:e661-671.
[2] 2021 Alzheimer's disease facts and figures[J]. Alzheimers Dement, 2021, 17:327-406.
[3] Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease:an analysis of population-based data[J]. Lancet Neurol, 2014, 13:788-794.
[4] Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER):a randomised controlled trial[J]. Lancet, 2015, 385:2255-2263.
[5] Huang P, Fang R, Li BY, Chen SD. Exercise-related changes of networks in aging and mild cognitive impairment brain[J]. Front Aging Neurosci, 2016, 8:47.
[6] Firth J, Stubbs B, Vancampfort D, Schuch F, Lagopoulos J, Rosenbaum S, Ward PB. Effect of aerobic exercise on hippocampal volume in humans:a systematic review and meta-analysis[J]. Neuroimage, 2018, 166:230-238.
[7] Sofi F, Valecchi D, Bacci D, Abbate R, Gensini GF, Casini A, Macchi C. Physical activity and risk of cognitive decline:a meta-analysis of prospective studies[J]. J Intern Med, 2011, 269:107-117.
[8] Santos-Lozano A, Pareja-Galeano H, Sanchis-Gomar F, Quindós-Rubial M, Fiuza-Luces C, Cristi-Montero C, Emanuele E, Garatachea N, Lucia A. Physical activity and Alzheimer disease:a protective association[J]. Mayo Clin Proc, 2016, 91:999-1020.
[9] Jia RX, Liang JH, Xu Y, Wang YQ. Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease:a meta-analysis[J]. BMC Geriatr, 2019, 19:181.
[10] Valenzuela PL, Castillo-García A, Morales JS, de la Villa P, Hampel H, Emanuele E, Lista S, Lucia A. Exercise benefits on Alzheimer's disease:state-of-the-science[J]. Ageing Res Rev, 2020, 62:101108.
[11] Trebbastoni A, Imbriano L, Podda L, Rendace L, Sacchetti ML, Campanelli A, D'Antonio F, de Lena C. Cognitive training in patients with Alzheimer's disease:findings of a 12-month randomized controlled trial[J]. Curr Alzheimer Res, 2018, 15:452-461.
[12] Livingston G, Johnston K, Katona C, Paton J, Lyketsos CG; Old Age Task Force of the World Federation of Biological Psychiatry. Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia[J]. Am J Psychiatry, 2005, 162:1996-2021.
[13] Iadecola C. Hypertension and dementia[J]. Hypertension, 2014, 64:3-5.
[14] Shalev D, Arbuckle MR. Metabolism and memory:obesity, diabetes, and dementia[J]. Biol Psychiatry, 2017, 82:e81-83.
[15] Kuo CY, Stachiv I, Nikolai T. Association of late life depression, (Non -) modifiable risk and protective factors with dementia and Alzheimer's disease:literature review on current evidences, preventive interventions and possible future trends in prevention and treatment of dementia[J]. Int J Environ Res Public Health, 2020, 17:7475.
[16] Avgerinos KI, Kalaitzidis G, Malli A, Kalaitzoglou D, Myserlis PG, Lioutas VA. Intranasal insulin in Alzheimer's dementia or mild cognitive impairment:a systematic review[J]. J Neurol, 2018, 265:1497-1510.
[17] González-Reyes RE, Aliev G, Ávila-Rodrigues M, Barreto GE. Alterations in glucose metabolism on cognition:a possible link between diabetes and dementia[J]. Curr Pharm Des, 2016, 22:812-818.
[18] Janelidze S, Stomrud E, Palmqvist S, Zetterberg H, van Westen D, Jeromin A, Song L, Hanlon D, Tan Hehir CA, Baker D, Blennow K, Hansson O. Plasma beta-amyloid in Alzheimer's disease and vascular disease[J]. Sci Rep, 2016, 6:26801.
[19] Wang H, Xu Y, Ren R, Yao F, Chen M, Sheng Z, Guo X, Li Y, Chen S, Wang G. Ambulatory blood pressure characteristics of patients with Alzheimer's disease:a multicenter study from China[J]. J Alzheimers Dis, 2021, 83:1333-1339.
[20] Perrotta M, Lembo G, Carnevale D. Hypertension and dementia:epidemiological and experimental evidence revealing a detrimental relationship[J]. Int J Mol Sci, 2016, 17:347.
[21] Murray MD, Hendrie HC, Lane KA, Zheng M, Ambuehl R, Li S, Unverzagt FW, Callahan CM, Gao S. Antihypertensive medication and dementia risk in older adult African Americans with hypertension:a prospective cohort study[J]. J Gen Intern Med, 2018, 33:455-462.
[22] Walker KA, Sharrett AR, Wu A, Schneider ALC, Albert M, Lutsey PL, Bandeen-Roche K, Coresh J, Gross AL, Windham BG, Knopman DS, Power MC, Rawlings AM, Mosley TH, Gottesman RF. Association of midlife to late -life blood pressure patterns with incident dementia[J]. JAMA, 2019, 322:535-545.
[23] Sabia S, Fayosse A, Dumurgier J, Dugravot A, Akbaraly T, Britton A, Kivimäki M, Singh-Manoux A. Alcohol consumption and risk of dementia:23 year follow-up of Whitehall Ⅱ cohort study[J]. BMJ, 2018, 362:k2927.
[24] Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A. Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension[J]. Am J Physiol Heart Circ Physiol, 2019, 316:H639-646.
[25] Choi D, Choi S, Park SM. Effect of smoking cessation on the risk of dementia:a longitudinal study[J]. Ann Clin Transl Neurol, 2018, 5:1192-1199.
[26] van Wanrooij LL, Borsboom D, Moll van Charante EP, Richard E, van Gool WA. A network approach on the relation between apathy and depression symptoms with dementia and functional disability[J]. Int Psychogeriatr, 2019, 31:1655-1663.
[27] Burke SL, Maramaldi P, Cadet T, Kukull W. Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer's disease:dementia[J]. Int Psychogeriatr, 2016, 28:1409-1424.
[28] Liguori C, Mercuri NB, Nuccetelli M, Izzi F, Cordella A, Bernardini S, Placidi F. Obstructive sleep apnea may induce orexinergic system and cerebral β-amyloid metabolism dysregulation:is it a further proof for Alzheimer's disease risk [J]? Sleep Med, 2019, 56:171-176.
[29] Richards KC, Gooneratne N, Dicicco B, Hanlon A, Moelter S, Onen F, Wang Y, Sawyer A, Weaver T, Lozano A, Carter P, Johnson J. CPAP adherence may slow 1-year cognitive decline in older adults with mild cognitive impairment and apnea[J]. J Am Geriatr Soc, 2019, 67:558-564.
[30] O'Connor DW, Ames D, Gardner B, King M. Psychosocial treatments of psychological symptoms in dementia:a systematic review of reports meeting quality standards[J]. Int Psychogeriatr, 2009, 21:241-251.
[31] Zhou Z, Wang P, Fang Y. Social engagement and its change are associated with dementia risk among Chinese older adults:a longitudinal study[J]. Sci Rep, 2018, 8:1551.
[32] Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia[J]. Alzheimers Dement (NY), 2017, 3:229-237.
[33] Wang Z, Marseglia A, Shang Y, Dintica C, Patrone C, Xu W. Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases:a population-based longitudinal study[J]. Alzheimers Dement, 2020, 16:316-325.
[34] Vanacore N, Blasimme A, Canevelli M. Aducanumab and Alzheimer's disease:a critical reflection[J]. Recenti Prog Med, 2021, 112:495-498.

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