Distribution and drug resistance of cerebrospinal fluid pathogenic bacteria in hospitalized patients

doi:10.3969/j.issn.1672-6731.2020.05.014

Abstract

Abstract:

Objective Retrospective analysis of the distribution of cerebrospinal fluid (CSF) pathogens and drug sensitivity test results in hospitalized neurosurgery patients, to provide a scientific basis for rational drug use. Methods A total of 2733 CSF specimens were collected from 2653 hospitalized patients with intracranial infection for bacterial identification and drug sensitivity tests from January 2016 to June 2018. Results A total of 207 pathogenic bacteria were isolated and the positive detection rate was 7.57% (207/2733). Among them, 115 strains of Gram-negative bacilli accounted for 57.21% (115/207), including 51 strains of Acinetobacter baumannii, 23 strains of Escherichia coli, 17 strains of Pseudomonas aeruginosa, 12 strains of Klebsiella pneumoniae, 7 strains of Enterobacter and other 5 cases; 86 strains of Gram-positive cocci accounted for 41.55% (86/207), 25 strains of Coagulase-negative staphylococci, 23 strains of Staphylococcus aureus, 19 strains of Streptococcus pneumoniae, 16 strains of Enterococcus, and other 3 cases; 1 strains of Gram-positive bacterium; 5 strains of Fungi. The resistance rates of Gram-negative bacilli to penicillins and cephalosporins were over 30%. The resistance rates of Gram-positive cocci to macrolides were over 40%. Conclusions Pathogens of intracranial infection were widely distributed and the rate of drug resistance was high. The drug resistance of hospitalized patients should be closely monitored and antibiotics should be used reasonably.

Key words: Cerebrospinal fluid, Bacteria, Cross infection, Drug tolerance, Inpatients

摘要：

目的对住院患者脑脊液病原菌分布及药敏试验结果进行回顾分析，为合理用药提供科学依据。方法采集2016年1月至2018年6月2653例颅内感染患者2733份脑脊液标本，分别行细菌鉴定和药敏试验。结果共分离获得致病性病原菌207株，阳性检出率7.57%（207/2733）。其中，革兰阴性杆菌115株占57.21%（115/207），包括鲍曼不动杆菌51株、大肠埃希菌23株、铜绿假单胞菌17株、肺炎克雷伯菌12株、阴沟肠杆菌7株、其他5例；革兰阳性球菌86株占41.55%（86/207），分别为凝固酶阴性葡萄球菌25株、金黄色葡萄球菌23株、肺炎链球菌19株、肠球菌16株、其他3株；革兰阳性杆菌1株；真菌5株。革兰阴性杆菌对青霉素类和头孢菌素类耐药率>30%，革兰阳性球菌对大环内酯类耐药率>40%。结论颅内感染致病菌分布广泛、耐药率较高，应严密监测住院病例细菌耐药情况，合理应用抗生素。

关键词: 脑脊髓液, 细菌, 交叉感染, 药物耐受性, 住院病人

SUN Deng-bin, WANG Meng, GUO Ye. Distribution and drug resistance of cerebrospinal fluid pathogenic bacteria in hospitalized patients[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(5): 455-459.

孙登彬, 王猛, 郭烨. 住院患者脑脊液病原菌分布及其耐药分析[J]. 中国现代神经疾病杂志, 2020, 20(5): 455-459.

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URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2020.05.014

https://journal11.magtechjournal.com/cjcnn/EN/Y2020/V20/I5/455

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