Advances in clinical diagnosis of Cushing's disease

doi:10.3969/j.issn.1672-6731.2020.03.006

Abstract

Abstract:

Cushing's disease, also known as pituitary adrenocorticotrophin-secreting adenoma, is a rare and serious neuroendocrine disease. At present, the diagnosis of disease is mainly based on the patient's clinical manifestations, imaging examinations and endocrine-related examinations. With the development of imaging technology, the refinement of laboratory tests and the maturation of genomics technology, the diagnostic level of the Cushing's disease has improved significantly. This article will review recent research advances on the qualitative and localized diagnosis of Cushing's disease in clinical manifestations, biochemical detection, imaging diagnostics, molecular markers and genomics detection.

Key words: Cushing syndrome, Pituitary neoplasms, Adrenocorticotropic hormone, Review

摘要：

库欣病亦称垂体促肾上腺皮质激素腺瘤，是一种临床罕见且严重的神经内分泌疾病。其诊断主要基于临床表现、影像学检查和内分泌功能测定。随着影像学技术的发展、实验室检查的精细化和基因组学技术的成熟，库欣病的诊断水平显著提高。本文拟从临床表现、影像学检查、内分泌功能测定、分子标志物检测和基因检测方面对库欣病的定性诊断和定位诊断进展进行综述。

关键词: 库欣综合征, 垂体肿瘤, 促肾上腺皮质激素, 综述

SUN Bo-wen, FENG Ming, ZHANG Jia-liang, KANG Jun. Advances in clinical diagnosis of Cushing's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(3): 162-165.

孙博文, 冯铭, 张家亮, 康军. 库欣病临床诊断研究进展[J]. 中国现代神经疾病杂志, 2020, 20(3): 162-165.

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