Abstract:

Disrupted in schizophrenia 1 (DISC1) is widely expressed in brain, and plays a role in multiple process of neurogenesis such as proliferation, migration, differentiation and maturation. DISC1 gene was found not only associated with mental disorders, such as schizophrenia, bipolar disorder and major depressive disorder, but also correlated with some neurological diseases, such as epilepsy. Our team have made efforts to clarify how DISC1 gene works in the regulation of neurogenesis and epileptogenesis. Here, we reviewed the DISC1 function on the development of neural stem cells (NSCs) and epileptogenesis.

Key words: DISC1 (not in MeSH), Neurons, Stem cells, Epilepsy, Review

摘要：

精神分裂症断裂基因1（DISC1）广泛表达于脑组织，对神经元生长发育的多个阶段，如增殖、迁移、分化和成熟均发挥调控作用。DISC1 基因不仅与精神分裂症、双相情感障碍和重度抑郁症等精神病的发病机制相关，还参与神经系统疾病，如癫的发生与发展。中南大学湘雅医院肖波教授研究团队致力于研究DISC1 基因及其相关蛋白在神经干细胞生长发育及癫发生发展中的调控作用。本文结合既往研究，展示我们研究团队相关成果，总结DISC1 基因及其相关蛋白在神经干细胞生长发育及癫发生发展中的分子生物学机制。

关键词: 精神分裂症断裂基因1（非MeSH 词）, 神经元, 干细胞, 癫, 综述