Abstract:

Objective To screen vascular risk factors for cognitive dysfunction in population with high risk of stroke by cognitive function evaluation on community people with high risk of stroke. Methods A total of 541 subjects who were screened with high risk of stroke from August to December 2012 in Yanta District of Xi'an, Shaanxi were evaluated by collecting baseline data and analyzing vascular risk factors. Mini-Mental State Examination (MMSE) was used to assess their cognitive function. Univariate and stepwise multivariate Logistic regression analysis were used to screen vascular risk factors for cognitive dysfunction in people with high risk of stroke. Results In those subjects, 90 people were identified as cognitive dysfunction, with a prevalence of 16.64% . Univariate and stepwise multivariate Logistic regression analysis showed that diabetes mellitus (OR = 1.871, 95% CI: 1.132-3.151; P = 0.015) was an independent risk factor for cognitive dysfunction in people with high risk of stroke. Conclusions Vascular risk factors could increase the risk of cognitive dysfunction, especially diabetes mellitus is the independent risk factor for cognitive dysfunction in people with high risk of stroke.

Key words: Stroke, Cognition disorders, Dementia, vascular, Risk factors, Regression analysis

摘要：

目的 通过对社区脑卒中高危人群进行认知功能评价，筛查脑卒中高危人群认知功能障碍的血管性危险因素。方法 对2012 年8-12 月在陕西省西安市雁塔区筛查出的541 例脑卒中高危人群进行翔实的基线资料采集和血管性危险因素评价，并采用简易智能状态检查量表评价认知功能。单因素和多因素逐步法Logistic 回归分析筛查脑卒中高危人群认知功能障碍的血管性危险因素。结果541 例脑卒中高危人群中90 例（16.64%）符合认知功能障碍标准，单因素和多因素逐步法Logistic 回归分析显示，仅糖尿病是脑卒中高危人群认知功能障碍的独立血管性危险因素（OR = 1.871，95%CI：1.132 ~3.151；P = 0.015）。结论 血管性危险因素可以增加认知功能障碍的发病风险，尤其糖尿病是脑卒中高危人群认知功能障碍的独立危险因素。

关键词: 卒中, 认知障碍, 痴呆, 血管性, 危险因素, 回归分析