Abstract:

Inflammatory reaction plays a crucial role in the occurence and development of atherosclerosis. Both basic and clinical trials have provided evidence that the expression of inflammatory biomarkers are closely related with the degree of atherosclerosis. Treatment towards inflammatory factors would bring benefit to atherosclerotic patients. This review highlighted the mechanistic rationale and specific therapies targeting traditional and novel inflammatory biomarkers, including C-reactive protein (CRP), interleukin-17 (IL-17), secretory phospholipase A2 (sPLA2), lipoprotein-associated phospholipase A2 (Lp-PLA2), endoglin, chemokine receptor and 5-lipoxygenase (5-LO), so as to review its mechanism of action and treatment prospect.

Key words: Atherosclerosis, Inflammation, Biological markers, Review

摘要：

炎症反应机制在动脉粥样硬化的发生与发展中发挥重要作用。多项基础与临床研究均提示炎性标志物表达变化与动脉粥样硬化程度密切相关，针对炎性因子的治疗可能给动脉粥样硬化患者带来益处。本文总结近年取得一些研究进展的传统和新型炎性标志物，如C-反应蛋白、白细胞介素-17、分泌型磷脂酶A2、脂蛋白相关磷脂酶A2、内皮糖蛋白、趋化因子受体和5 脂氧合酶等，从基础与临床角度综述其作用机制和治疗前景。

关键词: 动脉粥样硬化, 炎症, 生物学标记, 综述