Abstract:

The primary choice of treating refractory status epilepticus (RSE) is intravenous anesthetics, but the seizures of some patients can not get a good control. Thus, other therapies must be combined. Hypothermia not only can terminate seizures, but also play a part in brain protection. Though combined use of intravenous anesthetics and hypothermia is not a regular clinical scheme, the favorable effect has been proved by a lot of clinical research. This paper mainly focuses on the dose of intravenous anesthetics, the time, temperature and procedure of hypothermia, the indications and contraindications of combined therapy, and so on.

Key words: Status epilepticus, Intensive care units, Anesthetics, Hypothermia, Review

摘要：

静脉注射麻醉药物虽为治疗难治性癫痫持续状态的首选方法，但仍有部分患者不能有效控制发作，只能选择联合其他治疗方法。低温治疗不仅可以终止癫痫发作，尚具有一定脑保护作用。麻醉药物联合低温治疗终止癫痫持续状态的良好效果已被大量临床研究证实，本文拟对其麻醉药物剂量、低温施用时机、温度、具体方法，以及联合治疗适应证和禁忌证等进行概述，以使更多临床医师了解此项治疗措施的机制和应用方法。

关键词: 癫痫持续状态, 重症监护病房, 麻醉药, 低温, 综述