Abstract: Objective  To discuss the major indicing factors, clinical features, therapy and prognosis of toothbrushing-induced epilepsy.  Methods  The clinical manifestations, auxiliary examinations, treatment and prognosis were studied in 2 patients of toothbrushing-induced epilepsy, and related literatures were reviewed.  Results  Two sisters with toothbrushing-induced epilepsy were recruited in our study. Seizures began with facial numbness and convulsive tic, then involving right arm tic, and followed by loss of consciousness. One case was associated with tongue bite. They recovered after a few minutes without administration of any antiepileptic drugs (AEDs). Physical and neurological examination and brain MRI scan were normal. Prolonged video EEG (VEEG) recordings during wakefulness and sleep showed normal in the older sister, and spike-slow waves in the younger sister. After brushing their teeth less vigorously in shorter time, no seizure occurred. The patients had no further seizures during follow-up.  Conclusions  Toothbrushing-induced epilepsy is a rare kind of reflex epilepsy, and has tightly time-locked relationship with toothbrushing. Mild cases can be released by avoiding prolonged and vigorous brushing.

Key words: Epilepsy, reflex, Toothbrushing

摘要： 目的 探讨刷牙诱导癫痫的诱发因素、临床表现、治疗及预后。方法与结果 2 例患者系同胞姊妹，均为刷牙诱导癫痫发作，表现为口面部抽搐、单侧上肢抽搐伴意识丧失，数分钟后恢复，1 例伴舌咬伤，神经系统检查正常。头部MRI 无异常，脑电图1 例正常、1 例呈现发作间期尖-慢复合波。均未行抗癫痫药物治疗，嘱其避免用力刷牙、缩短刷牙时间后完全控制发作。结论 刷牙诱导癫痫是一种少见的反射性癫痫，癫痫发作与刷牙呈锁时关系，轻症患者降低刺激强度即可完全控制发作。

关键词: 癫痫, 反射性, 刷牙