Abstract: Sudden unexpected death in epilepsy (SUDEP) indicates sudden death without a definite cause in epileptics, especially during seizures or interictal phase. The risk of sudden death in epileptic patients is over 20 times higher than that in individuals without epilepsy. The explicit pathogenesis of SUDEP is not clear, while the heart disease is likely to play an important role in SUDEP. Cardiac dysfunction, which is caused by ion channel diseases, autonomic dysfunction, antiepileptic drugs (AEDs), is associated with SUDEP. Understanding of the mechanisms about cardiac factors is required to provide effective strategy for future control of SUDEP.

Key words: Epilepsy, Death, sudden, Heart diseases, Review

摘要： 癫痫猝死系指癫痫患者在发作期或发作间期突发的无法解释的死亡，其风险是普通人群的20 余倍。癫痫猝死存在多种机制，与心功能的相关性研究是目前研究的重要课题。癫痫和心脏离子通道病共存的遗传易感性、自主神经功能异常、抗癫痫药物等相关因素导致的心功能异常易诱发癫痫患者发生心源性猝死，进一步了解癫痫猝死发生过程中的心脏病变相关机制能够为制定预防和治疗策略提供理论基础。

关键词: 癫痫, 猝死, 心脏病, 综述